Cardiopulmonary Exercise Testing in Cancer Rehabilitation A Systematic Review

C.N. Steins Bisschop, M.J. Velthuis, H. Wittink, K. Kuiper, T. Takken, W.J.T.M. van der Meulen, E. Lindeman, P.H.M. Peeters, A.M. May

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

This systematic review aims to get insight into the feasibility of cardiopulmonary exercise testing (CPET) in patients with cancer prior to a physical exercise programme. We will focus on quality (defined as the adherence to international guidelines for methods of CPET) and safety of CPET. Furthermore, we compare the peak oxygen uptake ((V) over dotO(2peak)) values of patients with cancer with reference values for healthy persons to put these values into a clinical perspective. A computer aided search with 'cardiopulmonary exercise testing' and 'cancer' using MEDLINE, EMBASE, Pedro, CINAHL (R) and SPORTDiscus (TM) was carried out. We included studies in which CPET with continuous gas exchange analysis has been performed prior to a physical exercise programme in adults with cancer. Twenty studies describing 1158 patients were eligible. Reported adherence to international recommendations for CPET varied per item. In most studies, the methods of CPET were not reported in detail. Adverse events occurred in 1% of patients. The percentage (V) over dotO(2peak) of reference values for healthy persons varied between 65% and 89% for tests before treatment; between 74% and 96% for tests during treatment and between 52% and 117% for tests after treatment. Our results suggest that CPET is feasible and seems to be safe for patients with cancer prior to a physical exercise programme. We recommend that standard reporting and quality guidelines should be followed for CPET methods. The decreased (V) over dotO(2peak) values of patients with cancer indicate that physical exercise should be implemented in their standard care.

Original languageEnglish
Pages (from-to)367-379
Number of pages13
JournalSports Medicine
Volume42
Issue number5
Publication statusPublished - 2012

Keywords

  • RANDOMIZED CONTROLLED-TRIAL
  • QUALITY-OF-LIFE
  • CELL LUNG-CANCER
  • PATIENTS RECEIVING CHEMOTHERAPY
  • 30-YEAR FOLLOW-UP
  • DALLAS BED REST
  • BREAST-CANCER
  • AEROBIC EXERCISE
  • CARDIORESPIRATORY FITNESS
  • FUNCTIONAL-CAPACITY

Fingerprint

Dive into the research topics of 'Cardiopulmonary Exercise Testing in Cancer Rehabilitation A Systematic Review'. Together they form a unique fingerprint.

Cite this