Cardiogene shock door intoxicatie met fosfinegas

Translated title of the contribution: Cardiogenic shock due to phosphine poisoning

Jan W Buikema, Maarten J Cramer, Lienke de Vries Feyens, Martine Otten, Linda W van Laake, Mariusz Szymanski

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Toxic inhalations form a rare cause of poisoning in the Netherlands. The initial symptoms of toxic inhalations may appear similar to acute viral infections. In the maritime sector aluminum or zinc phosphide is used to overcome rodent infestations during transportation.

CASE DESCRIPTION: Here we discuss two patients intoxicated with gaseous phosphide used as fumigant in the transport of grains. The exposure to phosphide gas resulted in respiratory and gastrointestinal tract symptoms. Upon admission one of the patients deteriorated resulting in respiratory insufficiency, multi-organ failure and cardiogenic shock.

CONCLUSION: Phosphide gas poisoning forms a rare cause for transient acute heart and multiorgan failure largely due to mitochondria dysfunction. In the case of unexplained incapacitation of multiple patients and/or pets toxic inhalations should differentially diagnostically be considered.

Translated title of the contributionCardiogenic shock due to phosphine poisoning
Original languageDutch
JournalNederlands Tijdschrift voor Geneeskunde
Volume167
Publication statusPublished - 16 Mar 2023

Keywords

  • Humans
  • Gastrointestinal Diseases
  • Multiple Organ Failure/chemically induced
  • Phosphines/poisoning
  • Poisoning
  • Shock, Cardiogenic/chemically induced

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