TY - CHAP
T1 - Cardiac Regeneration and Repair
T2 - From Mechanisms to Therapeutic Strategies
AU - Sampaio-Pinto, Vasco
AU - Silva, Ana C.
AU - Pinto-do-Ó, Perpétua
AU - Nascimento, Diana S.
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2020.
PY - 2020
Y1 - 2020
N2 - Cardiovascular diseases lead the ranking of lethal causalities worldwide, which has been largely attributed to the limited regenerative capacity of the human heart. This restricted myocardial renewing capacity and exacerbated fibrosis often result in heart failure. Currently, the only long-term efficient therapy for this condition is whole-organ transplantation, which is limited by the shortage of donors and physiological constraints. Hence, several cutting-edge strategies to improve cardiac function, namely, gene and cellular therapies, biomaterial design and delivery, either solely or combined, are under investigation. In parallel, studies on heart development and on regenerative mechanisms evolutionarily conserved amongst species have highlighted molecules that hold potential for future therapeutic purposes. This perspective gained further relevance with recent advances showing that murine hearts display regenerative potential yet restrict to a limited period after birth. This chapter will revisit the regenerative capacity of the heart across species and throughout the lifespan, while discussing current advances in therapeutic alternatives for heart failure.
AB - Cardiovascular diseases lead the ranking of lethal causalities worldwide, which has been largely attributed to the limited regenerative capacity of the human heart. This restricted myocardial renewing capacity and exacerbated fibrosis often result in heart failure. Currently, the only long-term efficient therapy for this condition is whole-organ transplantation, which is limited by the shortage of donors and physiological constraints. Hence, several cutting-edge strategies to improve cardiac function, namely, gene and cellular therapies, biomaterial design and delivery, either solely or combined, are under investigation. In parallel, studies on heart development and on regenerative mechanisms evolutionarily conserved amongst species have highlighted molecules that hold potential for future therapeutic purposes. This perspective gained further relevance with recent advances showing that murine hearts display regenerative potential yet restrict to a limited period after birth. This chapter will revisit the regenerative capacity of the heart across species and throughout the lifespan, while discussing current advances in therapeutic alternatives for heart failure.
KW - Cardiac development
KW - Cardiac injury models
KW - Cardiac regeneration/repair
KW - Cardiac stem/progenitor cells
KW - Cardiomyocyte maturation
KW - Cardiomyocyte proliferation
KW - Cardiovascular diseases
KW - Cell cycle arrest
KW - Heart failure
KW - Neonatal heart
UR - https://www.scopus.com/pages/publications/105033602537
U2 - 10.1007/978-3-030-43939-2_10
DO - 10.1007/978-3-030-43939-2_10
M3 - Chapter
AN - SCOPUS:105033602537
SN - 978-3-030-43938-5
T3 - Learning Materials in Biosciences
SP - 187
EP - 211
BT - Concepts and Applications of Stem Cell Biology
PB - Springer
ER -