Cardiac dysfunction in pneumovirus-induced lung injury in mice

Reinout A Bem; Elske van den Berg; Ernst Suidgeest; Louise van der Weerd; Job B M van Woensel; Heynric B Grotenhuis

doi:10.1097/PCC.0b013e31828a7f9b

Cardiac dysfunction in pneumovirus-induced lung injury in mice

Reinout A Bem
, Elske van den Berg
, Ernst Suidgeest
, Louise van der Weerd
, Job B M van Woensel
, Heynric B Grotenhuis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.

DESIGN: Experimental animal study.

SETTING: Animal laboratory.

SUBJECTS: C57Bl/6 mice.

INTERVENTION: Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.

MEASUREMENTS AND MAIN RESULTS: Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.

CONCLUSIONS: These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.

Original language	English
Pages (from-to)	e243-9
Journal	Pediatric Critical Care Medicine
Volume	14
Issue number	5
DOIs	https://doi.org/10.1097/PCC.0b013e31828a7f9b
Publication status	Published - Jun 2013
Externally published	Yes

Keywords

Acute Lung Injury/etiology
Animals
Cytokines/blood
Disease Models, Animal
Female
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Pneumovirus Infections/complications
Stroke Volume
Ventricular Dysfunction/etiology

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10.1097/PCC.0b013e31828a7f9b

Cite this

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title = "Cardiac dysfunction in pneumovirus-induced lung injury in mice",

abstract = "OBJECTIVE: To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.DESIGN: Experimental animal study.SETTING: Animal laboratory.SUBJECTS: C57Bl/6 mice.INTERVENTION: Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.MEASUREMENTS AND MAIN RESULTS: Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.CONCLUSIONS: These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.",

keywords = "Acute Lung Injury/etiology, Animals, Cytokines/blood, Disease Models, Animal, Female, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Pneumovirus Infections/complications, Stroke Volume, Ventricular Dysfunction/etiology",

author = "Bem, \{Reinout A\} and \{van den Berg\}, Elske and Ernst Suidgeest and \{van der Weerd\}, Louise and \{van Woensel\}, \{Job B M\} and Grotenhuis, \{Heynric B\}",

year = "2013",

month = jun,

doi = "10.1097/PCC.0b013e31828a7f9b",

language = "English",

volume = "14",

pages = "e243--9",

journal = "Pediatric Critical Care Medicine",

issn = "1529-7535",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "5",

}

TY - JOUR

T1 - Cardiac dysfunction in pneumovirus-induced lung injury in mice

AU - Bem, Reinout A

AU - van den Berg, Elske

AU - Suidgeest, Ernst

AU - van der Weerd, Louise

AU - van Woensel, Job B M

AU - Grotenhuis, Heynric B

PY - 2013/6

Y1 - 2013/6

N2 - OBJECTIVE: To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.DESIGN: Experimental animal study.SETTING: Animal laboratory.SUBJECTS: C57Bl/6 mice.INTERVENTION: Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.MEASUREMENTS AND MAIN RESULTS: Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.CONCLUSIONS: These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.

AB - OBJECTIVE: To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.DESIGN: Experimental animal study.SETTING: Animal laboratory.SUBJECTS: C57Bl/6 mice.INTERVENTION: Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.MEASUREMENTS AND MAIN RESULTS: Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.CONCLUSIONS: These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.

KW - Acute Lung Injury/etiology

KW - Animals

KW - Cytokines/blood

KW - Disease Models, Animal

KW - Female

KW - Magnetic Resonance Imaging

KW - Mice

KW - Mice, Inbred C57BL

KW - Pneumovirus Infections/complications

KW - Stroke Volume

KW - Ventricular Dysfunction/etiology

U2 - 10.1097/PCC.0b013e31828a7f9b

DO - 10.1097/PCC.0b013e31828a7f9b

M3 - Article

C2 - 23867445

SN - 1529-7535

VL - 14

SP - e243-9

JO - Pediatric Critical Care Medicine

JF - Pediatric Critical Care Medicine

IS - 5

ER -

Cardiac dysfunction in pneumovirus-induced lung injury in mice

Abstract

Keywords

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