Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance

Jan M. Leerink; E. C. De Baat; Elizabeth Lieke A.M. Feijen; L. Bellersen; E.C. van Dalen; L. Kapusta; Heynric Grotenhuis; Wouter E M Kok; Jacqueline J Loonen; Heleen van der Pal; Saskia Pluijm; Arco Teske; Annelies M C Mavinkurve-Groothuis; Remy Merkx; Leontien C M Kremer

doi:10.1016/j.jaccao.2020.08.006

Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance

Jan M. Leerink, E. C. De Baat, Elizabeth Lieke A.M. Feijen, L. Bellersen, E.C. van Dalen, L. Kapusta, Heynric Grotenhuis, Wouter E M Kok, Jacqueline J Loonen, Heleen van der Pal, Saskia Pluijm, Arco Teske, Annelies M C Mavinkurve-Groothuis, Remy Merkx, Leontien C M Kremer^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Cardiac diseases in the growing population of childhood cancer survivors are of major concern. Cardiotoxicity as a consequence of anthracyclines and chest radiotherapy continues to be relevant in the modern treatment era. Mitoxantrone has emerged as an important treatment-related risk factor and evidence on traditional cardiovascular risk factors in childhood cancer survivors is accumulating. International surveillance guidelines have been developed with the aim to detect and manage cardiac diseases early and prevent symptomatic disease. There is growing interest in risk prediction models to individualize prevention and surveillance. This State-of-the-Art Review summarizes literature from a systematic PubMed search focused on cardiac diseases after treatment for childhood cancer. Here, we discuss the prevalence, risk factors, prevention, risk prediction, and surveillance of cardiac diseases in survivors of childhood cancer

Original language	English
Article number	3
Pages (from-to)	363-378
Number of pages	16
Journal	J AM Coll Cardiol CardioOnc
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.jaccao.2020.08.006
Publication status	Published - Sept 2020

Keywords

risk prediction
prevention
childhood cancer survivors
cardiotoxicity
cardiovascular risk factors

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1-s2.0-S2666087320301782-mainFinal published version, 2.52 MBLicence: CC BY-NC-ND

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Leerink, J. M., De Baat, E. C., Feijen, E. L. A. M., Bellersen, L., van Dalen, E. C., Kapusta, L., Grotenhuis, H., Kok, W. E. M., Loonen, J. J., van der Pal, H., Pluijm, S., Teske, A., Mavinkurve-Groothuis, A. M. C., Merkx, R., & Kremer, L. C. M. (2020). Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance. J AM Coll Cardiol CardioOnc, 2(3), 363-378. Article 3. https://doi.org/10.1016/j.jaccao.2020.08.006

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title = "Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance",

abstract = "Cardiac diseases in the growing population of childhood cancer survivors are of major concern. Cardiotoxicity as a consequence of anthracyclines and chest radiotherapy continues to be relevant in the modern treatment era. Mitoxantrone has emerged as an important treatment-related risk factor and evidence on traditional cardiovascular risk factors in childhood cancer survivors is accumulating. International surveillance guidelines have been developed with the aim to detect and manage cardiac diseases early and prevent symptomatic disease. There is growing interest in risk prediction models to individualize prevention and surveillance. This State-of-the-Art Review summarizes literature from a systematic PubMed search focused on cardiac diseases after treatment for childhood cancer. Here, we discuss the prevalence, risk factors, prevention, risk prediction, and surveillance of cardiac diseases in survivors of childhood cancer",

keywords = "risk prediction, prevention, childhood cancer survivors, cardiotoxicity, cardiovascular risk factors",

author = "Leerink, {Jan M.} and {De Baat}, {E. C.} and Feijen, {Elizabeth Lieke A.M.} and L. Bellersen and {van Dalen}, E.C. and L. Kapusta and Heynric Grotenhuis and Kok, {Wouter E M} and Loonen, {Jacqueline J} and {van der Pal}, Heleen and Saskia Pluijm and Arco Teske and Mavinkurve-Groothuis, {Annelies M C} and Remy Merkx and Kremer, {Leontien C M}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = sep,

doi = "10.1016/j.jaccao.2020.08.006",

language = "English",

volume = "2",

pages = "363--378",

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Leerink, JM, De Baat, EC, Feijen, ELAM, Bellersen, L, van Dalen, EC, Kapusta, L, Grotenhuis, H, Kok, WEM, Loonen, JJ, van der Pal, H, Pluijm, S, Teske, A, Mavinkurve-Groothuis, AMC, Merkx, R & Kremer, LCM 2020, 'Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance', J AM Coll Cardiol CardioOnc, vol. 2, no. 3, 3, pp. 363-378. https://doi.org/10.1016/j.jaccao.2020.08.006

TY - JOUR

T1 - Cardiac Disease in Childhood Cancer Survivors

T2 - Risk Prediction, Prevention, and Surveillance

AU - Leerink, Jan M.

AU - De Baat, E. C.

AU - Feijen, Elizabeth Lieke A.M.

AU - Bellersen, L.

AU - van Dalen, E.C.

AU - Kapusta, L.

AU - Grotenhuis, Heynric

AU - Kok, Wouter E M

AU - Loonen, Jacqueline J

AU - van der Pal, Heleen

AU - Pluijm, Saskia

AU - Teske, Arco

AU - Mavinkurve-Groothuis, Annelies M C

AU - Merkx, Remy

AU - Kremer, Leontien C M

PY - 2020/9

Y1 - 2020/9

N2 - Cardiac diseases in the growing population of childhood cancer survivors are of major concern. Cardiotoxicity as a consequence of anthracyclines and chest radiotherapy continues to be relevant in the modern treatment era. Mitoxantrone has emerged as an important treatment-related risk factor and evidence on traditional cardiovascular risk factors in childhood cancer survivors is accumulating. International surveillance guidelines have been developed with the aim to detect and manage cardiac diseases early and prevent symptomatic disease. There is growing interest in risk prediction models to individualize prevention and surveillance. This State-of-the-Art Review summarizes literature from a systematic PubMed search focused on cardiac diseases after treatment for childhood cancer. Here, we discuss the prevalence, risk factors, prevention, risk prediction, and surveillance of cardiac diseases in survivors of childhood cancer

AB - Cardiac diseases in the growing population of childhood cancer survivors are of major concern. Cardiotoxicity as a consequence of anthracyclines and chest radiotherapy continues to be relevant in the modern treatment era. Mitoxantrone has emerged as an important treatment-related risk factor and evidence on traditional cardiovascular risk factors in childhood cancer survivors is accumulating. International surveillance guidelines have been developed with the aim to detect and manage cardiac diseases early and prevent symptomatic disease. There is growing interest in risk prediction models to individualize prevention and surveillance. This State-of-the-Art Review summarizes literature from a systematic PubMed search focused on cardiac diseases after treatment for childhood cancer. Here, we discuss the prevalence, risk factors, prevention, risk prediction, and surveillance of cardiac diseases in survivors of childhood cancer

KW - risk prediction

KW - prevention

KW - childhood cancer survivors

KW - cardiotoxicity

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U2 - 10.1016/j.jaccao.2020.08.006

DO - 10.1016/j.jaccao.2020.08.006

M3 - Review article

C2 - 34396245

SN - 2666-0873

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SP - 363

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JO - J AM Coll Cardiol CardioOnc

JF - J AM Coll Cardiol CardioOnc

IS - 3

M1 - 3

ER -

Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance

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