CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models

Antonio Carlos Tallon-Cobos; Konstantinos Vazaios; Piotr Waranecki; Marliek van Hoesel; Annelisa Cornel; Benjamin Schwalm; Norman Mack; Ella de Boed; Jasper van der Lugt; Stefan Nierkens; Marcel Kool; Eelco W. Hoving; Dennis S. Metselaar; Esther Hulleman

doi:10.1172/JCI193332

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models

Antonio Carlos Tallon-Cobos
, Konstantinos Vazaios
, Piotr Waranecki
, Marliek van Hoesel
, Annelisa Cornel
, Benjamin Schwalm
, Norman Mack
, Ella de Boed
, Jasper van der Lugt
, Stefan Nierkens
, Marcel Kool
, Eelco W. Hoving
, Dennis S. Metselaar
, Esther Hulleman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aggressive pediatric brain tumor models of ependymoma are highly sensitive to GD2-directed (CAR T) cell therapy.

Original language	English
Journal	The Journal of clinical investigation
Volume	136
Issue number	2
DOIs	https://doi.org/10.1172/JCI193332
Publication status	Published - 16 Jan 2026

Keywords

Brain cancer
Cancer immunotherapy
Immunology
Neuroscience
Oncology

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10.1172/JCI193332Licence: CC BY

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma modelsFinal published version, 2.9 MBLicence: CC BY

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Tallon-Cobos, A. C., Vazaios, K., Waranecki, P., van Hoesel, M., Cornel, A., Schwalm, B., Mack, N., de Boed, E., van der Lugt, J., Nierkens, S., Kool, M., Hoving, E. W., Metselaar, D. S., & Hulleman, E. (2026). CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models. The Journal of clinical investigation, 136(2). https://doi.org/10.1172/JCI193332

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title = "CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models",

abstract = "Aggressive pediatric brain tumor models of ependymoma are highly sensitive to GD2-directed (CAR T) cell therapy.",

keywords = "Brain cancer, Cancer immunotherapy, Immunology, Neuroscience, Oncology",

author = "Tallon-Cobos, \{Antonio Carlos\} and Konstantinos Vazaios and Piotr Waranecki and \{van Hoesel\}, Marliek and Annelisa Cornel and Benjamin Schwalm and Norman Mack and \{de Boed\}, Ella and \{van der Lugt\}, Jasper and Stefan Nierkens and Marcel Kool and Hoving, \{Eelco W.\} and Metselaar, \{Dennis S.\} and Esther Hulleman",

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month = jan,

day = "16",

doi = "10.1172/JCI193332",

language = "English",

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journal = "The Journal of clinical investigation",

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Tallon-Cobos, AC, Vazaios, K, Waranecki, P, van Hoesel, M, Cornel, A, Schwalm, B, Mack, N, de Boed, E, van der Lugt, J, Nierkens, S, Kool, M, Hoving, EW, Metselaar, DS & Hulleman, E 2026, 'CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models', The Journal of clinical investigation, vol. 136, no. 2. https://doi.org/10.1172/JCI193332

TY - JOUR

T1 - CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models

AU - Tallon-Cobos, Antonio Carlos

AU - Vazaios, Konstantinos

AU - Waranecki, Piotr

AU - van Hoesel, Marliek

AU - Cornel, Annelisa

AU - Schwalm, Benjamin

AU - Mack, Norman

AU - de Boed, Ella

AU - van der Lugt, Jasper

AU - Nierkens, Stefan

AU - Kool, Marcel

AU - Hoving, Eelco W.

AU - Metselaar, Dennis S.

AU - Hulleman, Esther

PY - 2026/1/16

Y1 - 2026/1/16

N2 - Aggressive pediatric brain tumor models of ependymoma are highly sensitive to GD2-directed (CAR T) cell therapy.

AB - Aggressive pediatric brain tumor models of ependymoma are highly sensitive to GD2-directed (CAR T) cell therapy.

KW - Brain cancer

KW - Cancer immunotherapy

KW - Immunology

KW - Neuroscience

KW - Oncology

UR - https://www.scopus.com/pages/publications/105027685317

U2 - 10.1172/JCI193332

DO - 10.1172/JCI193332

M3 - Article

C2 - 41289021

AN - SCOPUS:105027685317

SN - 1558-8238

VL - 136

JO - The Journal of clinical investigation

JF - The Journal of clinical investigation

IS - 2

ER -

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models

Abstract

Keywords

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