CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

Nina Worel; Jarl E Mooyaart; Jorinde D Hoogenboom; Michael Daskalakis; Jean-Jacques Tudesq; Ron Ram; Vladan Vucinic; Stefania Bramanti; Lucía López Corral; Emma Nicholson; Robert Zeiser; Friedrich Stölzel; Eugenio Galli; Simona Pagliuca; Eva Wagner-Drouet; Friso Calkoen; Christian Chabannon; Florent Malard; Annalisa Ruggeri; Jürgen Kuball

doi:10.1038/s41409-025-02623-0

CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

Nina Worel^*
, Jarl E Mooyaart
, Jorinde D Hoogenboom
, Michael Daskalakis
, Jean-Jacques Tudesq
, Ron Ram
, Vladan Vucinic
, Stefania Bramanti
, Lucía López Corral
, Emma Nicholson
, Robert Zeiser
, Friedrich Stölzel
, Eugenio Galli
, Simona Pagliuca
, Eva Wagner-Drouet
, Friso Calkoen
, Christian Chabannon
, Florent Malard
, Annalisa Ruggeri
, Jürgen Kuball

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

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Original language	English
Article number	345
Pages (from-to)	1184–1186
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	60
Issue number	8
Early online date	15 May 2025
DOIs	https://doi.org/10.1038/s41409-025-02623-0
Publication status	Published - Aug 2025

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10.1038/s41409-025-02623-0

s41409-025-02623-0Final published version, 616 KBLicence: Taverne

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Worel, N., Mooyaart, J. E., Hoogenboom, J. D., Daskalakis, M., Tudesq, J.-J., Ram, R., Vucinic, V., Bramanti, S., Corral, L. L., Nicholson, E., Zeiser, R., Stölzel, F., Galli, E., Pagliuca, S., Wagner-Drouet, E., Calkoen, F., Chabannon, C., Malard, F., Ruggeri, A., & Kuball, J. (2025). CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party. Bone Marrow Transplantation, 60(8), 1184–1186 . Article 345. https://doi.org/10.1038/s41409-025-02623-0

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title = "CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party",

author = "Nina Worel and Mooyaart, \{Jarl E\} and Hoogenboom, \{Jorinde D\} and Michael Daskalakis and Jean-Jacques Tudesq and Ron Ram and Vladan Vucinic and Stefania Bramanti and Corral, \{Luc{\'i}a L{\'o}pez\} and Emma Nicholson and Robert Zeiser and Friedrich St{\"o}lzel and Eugenio Galli and Simona Pagliuca and Eva Wagner-Drouet and Friso Calkoen and Christian Chabannon and Florent Malard and Annalisa Ruggeri and J{\"u}rgen Kuball",

year = "2025",

month = aug,

doi = "10.1038/s41409-025-02623-0",

language = "English",

volume = "60",

pages = "1184–1186 ",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

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Worel, N, Mooyaart, JE, Hoogenboom, JD, Daskalakis, M, Tudesq, J-J, Ram, R, Vucinic, V, Bramanti, S, Corral, LL, Nicholson, E, Zeiser, R, Stölzel, F, Galli, E, Pagliuca, S, Wagner-Drouet, E, Calkoen, F, Chabannon, C, Malard, F, Ruggeri, A & Kuball, J 2025, 'CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party', Bone Marrow Transplantation, vol. 60, no. 8, 345, pp. 1184–1186 . https://doi.org/10.1038/s41409-025-02623-0

CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party. / Worel, Nina; Mooyaart, Jarl E; Hoogenboom, Jorinde D et al.
In: Bone Marrow Transplantation, Vol. 60, No. 8, 345, 08.2025, p. 1184–1186 .

Research output: Contribution to journal › Letter › Academic › peer-review

TY - JOUR

T1 - CAR-T cell manufacturing failures and out-of-specification products in the real-world setting

T2 - A survey from the EBMT cellular therapy and immunobiology working party

AU - Worel, Nina

AU - Mooyaart, Jarl E

AU - Hoogenboom, Jorinde D

AU - Daskalakis, Michael

AU - Tudesq, Jean-Jacques

AU - Ram, Ron

AU - Vucinic, Vladan

AU - Bramanti, Stefania

AU - Corral, Lucía López

AU - Nicholson, Emma

AU - Zeiser, Robert

AU - Stölzel, Friedrich

AU - Galli, Eugenio

AU - Pagliuca, Simona

AU - Wagner-Drouet, Eva

AU - Calkoen, Friso

AU - Chabannon, Christian

AU - Malard, Florent

AU - Ruggeri, Annalisa

AU - Kuball, Jürgen

PY - 2025/8

Y1 - 2025/8

UR - https://www.scopus.com/pages/publications/105005091594

U2 - 10.1038/s41409-025-02623-0

DO - 10.1038/s41409-025-02623-0

M3 - Letter

C2 - 40374897

SN - 0268-3369

VL - 60

SP - 1184

EP - 1186

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 8

M1 - 345

ER -

CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

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