Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae

Krzysztof Trzciński; Adam MacNeil; Keith P. Klugman; Marc Lipsitch

doi:10.1128/AAC.49.4.1591-1592.2005

Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae

Krzysztof Trzciński^*
, Adam MacNeil
, Keith P. Klugman
, Marc Lipsitch

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.

Original language	English
Pages (from-to)	1591-1592
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	4
DOIs	https://doi.org/10.1128/AAC.49.4.1591-1592.2005
Publication status	Published - 1 Apr 2005

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10.1128/AAC.49.4.1591-1592.2005

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title = "Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae",

abstract = "Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.",

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Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae. / Trzciński, Krzysztof; MacNeil, Adam; Klugman, Keith P. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 4, 01.04.2005, p. 1591-1592.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae

AU - Trzciński, Krzysztof

AU - MacNeil, Adam

AU - Klugman, Keith P.

AU - Lipsitch, Marc

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.

AB - Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.

UR - https://www.scopus.com/pages/publications/16244365823

U2 - 10.1128/AAC.49.4.1591-1592.2005

DO - 10.1128/AAC.49.4.1591-1592.2005

M3 - Article

C2 - 15793147

AN - SCOPUS:16244365823

SN - 0066-4804

VL - 49

SP - 1591

EP - 1592

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

ER -

Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae

Abstract

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