TY - JOUR
T1 - Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae
AU - Trzciński, Krzysztof
AU - MacNeil, Adam
AU - Klugman, Keith P.
AU - Lipsitch, Marc
PY - 2005/4/1
Y1 - 2005/4/1
N2 - Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.
AB - Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.
UR - https://www.scopus.com/pages/publications/16244365823
U2 - 10.1128/AAC.49.4.1591-1592.2005
DO - 10.1128/AAC.49.4.1591-1592.2005
M3 - Article
C2 - 15793147
AN - SCOPUS:16244365823
SN - 0066-4804
VL - 49
SP - 1591
EP - 1592
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -