TY - JOUR
T1 - Canola oil compared with sesame and sesame-canola oil on glycaemic control and liver function in patients with type 2 diabetes
T2 - A three-way randomized triple-blind cross-over trial
AU - Raeisi-Dehkordi, Hamidreza
AU - Amiri, Mojgan
AU - Zimorovat, Alireza
AU - Moghtaderi, Fatemeh
AU - Zarei, Sadegh
AU - Forbes, Scott C.
AU - Salehi-Abargouei, Amin
N1 - Funding Information:
We appreciate the participants for their voluntary involvement in the project. We would like to thank the research council of Nutrition and Food Security Research Center and diabetes research centre of Shahid Sadoughi University of Medical Sciences, Yazd, Iran, for their scientific support and close cooperation. The present study was funded by Shahid Sadoughi University of Medical Sciences and all of intervention oils were provided by Neshatavar industry (Datis oil corporation; http://www.neshatavar.com/?l=EN). The investigators received financial support for other projects studying the effect of intervention oils and also gene-oil interactions on cardio-metabolic markers from Datis oil corporation. However, no external financial support was received for the current analyses. The authors state that they have no financial relationship with Datis Corporation other than research. Datis corporation had no role in the design, conduction; data collection, management, analysis, interpretation of the data or in the presentation of this manuscript.
Funding Information:
We appreciate the participants for their voluntary involvement in the project. We would like to thank the research council of Nutrition and Food Security Research Center and diabetes research centre of Shahid Sadoughi University of Medical Sciences, Yazd, Iran, for their scientific support and close cooperation. The present study was funded by Shahid Sadoughi University of Medical Sciences and all of intervention oils were provided by Neshatavar industry (Datis oil corporation; http://www.neshatavar.com/?l=EN ). The investigators received financial support for other projects studying the effect of intervention oils and also gene‐oil interactions on cardio‐metabolic markers from Datis oil corporation. However, no external financial support was received for the current analyses. The authors state that they have no financial relationship with Datis Corporation other than research. Datis corporation had no role in the design, conduction; data collection, management, analysis, interpretation of the data or in the presentation of this manuscript.
Publisher Copyright:
© 2020 John Wiley & Sons Ltd.
PY - 2021/7
Y1 - 2021/7
N2 - Background: This study aimed to compare the effects of sesame (SO), canola (CO), and sesame-canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 diabetes. Methods: In this randomized, triple-blind, three-way, cross-over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), insulin sensitivity (HOMA2-%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods. Results: Ninety-two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2-%S (p < 0.05). SO and SCO led to favourable changes in HOMA2-IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2-%B (p < 0.05). The sex-stratified analysis revealed that FSI and HOMA2-IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma-glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058). Conclusions: SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).
AB - Background: This study aimed to compare the effects of sesame (SO), canola (CO), and sesame-canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 diabetes. Methods: In this randomized, triple-blind, three-way, cross-over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), insulin sensitivity (HOMA2-%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods. Results: Ninety-two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2-%S (p < 0.05). SO and SCO led to favourable changes in HOMA2-IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2-%B (p < 0.05). The sex-stratified analysis revealed that FSI and HOMA2-IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma-glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058). Conclusions: SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).
KW - canola oil
KW - glycaemic control
KW - liver function enzymes
KW - rapeseed oil
KW - sesame oil
KW - type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85090434604&partnerID=8YFLogxK
U2 - 10.1002/dmrr.3399
DO - 10.1002/dmrr.3399
M3 - Article
C2 - 32860716
AN - SCOPUS:85090434604
SN - 1520-7552
VL - 37
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
IS - 5
M1 - e3399
ER -