Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

L. C. van der Wekken-Pas; P. J. de Haas; R. Wisse; M. Rados; K. C.M. van der Elst

doi:10.1177/11206721211060140

Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

L. C. van der Wekken-Pas^*, P. J. de Haas, R. Wisse, M. Rados, K. C.M. van der Elst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.

Original language	English
Pages (from-to)	NP73-NP78
Journal	European Journal of Ophthalmology
Volume	33
Issue number	2
DOIs	https://doi.org/10.1177/11206721211060140
Publication status	Published - Mar 2023

Keywords

antifungals
corneal transplantation
endophtalmitis
fungal infection
Keratitis
pharmacotherapy

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title = "Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options",

abstract = "Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.",

keywords = "antifungals, corneal transplantation, endophtalmitis, fungal infection, Keratitis, pharmacotherapy",

author = "\{van der Wekken-Pas\}, \{L. C.\} and \{de Haas\}, \{P. J.\} and R. Wisse and M. Rados and \{van der Elst\}, \{K. C.M.\}",

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year = "2023",

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doi = "10.1177/11206721211060140",

language = "English",

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Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options. / van der Wekken-Pas, L. C.; de Haas, P. J.; Wisse, R. et al.
In: European Journal of Ophthalmology, Vol. 33, No. 2, 03.2023, p. NP73-NP78.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

AU - van der Wekken-Pas, L. C.

AU - de Haas, P. J.

AU - Wisse, R.

AU - Rados, M.

AU - van der Elst, K. C.M.

N1 - Publisher Copyright: © The Author(s) 2021.

PY - 2023/3

Y1 - 2023/3

N2 - Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.

AB - Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.

KW - antifungals

KW - corneal transplantation

KW - endophtalmitis

KW - fungal infection

KW - Keratitis

KW - pharmacotherapy

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DO - 10.1177/11206721211060140

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SN - 1120-6721

VL - 33

SP - NP73-NP78

JO - European Journal of Ophthalmology

JF - European Journal of Ophthalmology

IS - 2

ER -

Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

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