Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

L. C. van der Wekken-Pas; P. J. de Haas; R. Wisse; M. Rados; K. C.M. van der Elst

doi:10.1177/11206721211060140

Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

L. C. van der Wekken-Pas^*, P. J. de Haas, R. Wisse, M. Rados, K. C.M. van der Elst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Downloads (Pure)

Abstract

Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.

Original language	English
Pages (from-to)	NP73-NP78
Journal	European Journal of Ophthalmology
Volume	33
Issue number	2
DOIs	https://doi.org/10.1177/11206721211060140
Publication status	Published - Mar 2023

Keywords

antifungals
corneal transplantation
endophtalmitis
fungal infection
Keratitis
pharmacotherapy

Access to Document

10.1177/11206721211060140Licence: CC BY

van-der-wekken-pas-et-al-2021-candida-keratitis-and-endopthalmitis-after-corneal-transplantation-two-case-reports-aFinal published version, 6.76 MBLicence: CC BY

Cite this

@article{17acd76d23c54e3ca2aa027b7649ef9e,

title = "Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options",

abstract = "Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.",

keywords = "antifungals, corneal transplantation, endophtalmitis, fungal infection, Keratitis, pharmacotherapy",

author = "{van der Wekken-Pas}, {L. C.} and {de Haas}, {P. J.} and R. Wisse and M. Rados and {van der Elst}, {K. C.M.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021.",

year = "2023",

month = mar,

doi = "10.1177/11206721211060140",

language = "English",

volume = "33",

pages = "NP73--NP78",

journal = "European Journal of Ophthalmology",

issn = "1120-6721",

publisher = "Wichtig Publishing",

number = "2",

}

Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options. / van der Wekken-Pas, L. C.; de Haas, P. J.; Wisse, R. et al.
In: European Journal of Ophthalmology, Vol. 33, No. 2, 03.2023, p. NP73-NP78.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

AU - van der Wekken-Pas, L. C.

AU - de Haas, P. J.

AU - Wisse, R.

AU - Rados, M.

AU - van der Elst, K. C.M.

N1 - Publisher Copyright: © The Author(s) 2021.

PY - 2023/3

Y1 - 2023/3

N2 - Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.

AB - Purpose: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. Methods: Case reports and literature review. Results: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. Conclusions: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.

KW - antifungals

KW - corneal transplantation

KW - endophtalmitis

KW - fungal infection

KW - Keratitis

KW - pharmacotherapy

UR - http://www.scopus.com/inward/record.url?scp=85120657867&partnerID=8YFLogxK

U2 - 10.1177/11206721211060140

DO - 10.1177/11206721211060140

M3 - Article

C2 - 34812090

AN - SCOPUS:85120657867

SN - 1120-6721

VL - 33

SP - NP73-NP78

JO - European Journal of Ophthalmology

JF - European Journal of Ophthalmology

IS - 2

ER -

Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this