TY - JOUR
T1 - Cam morphology and the risk of developing radiographic hip osteoarthritis within 8 years
T2 - an individual participant data meta-analysis of 23 886 hips from the world COACH consortium
AU - Tang, Jinchi
AU - Boel, Fleur
AU - van Buuren, Michiel Ma
AU - Riedstra, Noortje S
AU - van den Berg, Myrthe A
AU - Ahedi, Harbeer
AU - Arden, Nigel K
AU - Bierma-Zeinstra, Sita M A
AU - Boer, Cindy G
AU - Cicutini, Flavia
AU - Cootes, Timothy
AU - Crossley, Kay M
AU - Felson, David T
AU - Gielis, Willem-Paul
AU - Heerey, Joshua J
AU - Jones, Graeme
AU - Kluzek, Stefan
AU - Lane, Nancy E
AU - Lindner, Claudia
AU - Lynch, John A
AU - van Meurs, Joyce
AU - Mosler, Andrea Britt
AU - Nelson, Amanda E
AU - Nevitt, Michael
AU - Oei, Edwin H G
AU - Runhaar, Jos
AU - Weinans, Harrie
AU - Agricola, Rintje
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
PY - 2026/1/15
Y1 - 2026/1/15
N2 - OBJECTIVE: To assess the relationship between cam morphology and the development of radiographic hip osteoarthritis (RHOA), overall and in subgroups based on age, biological sex and body mass index (BMI).METHODS: Hips with no RHOA at baseline and with available follow-up during 4-8 years were selected from the Worldwide Collaboration on Osteoarthritis PrediCtion for the Hip (World COACH) consortium. Alpha angles were uniformly measured on anteroposterior radiographs, with a threshold of 60° used to define cam morphology. Incident RHOA was defined as the transition from an RHOA-free state at baseline to definite diagnosis of RHOA at follow-up. The association between baseline cam morphology and the development of RHOA was assessed using a three-level mixed-effects logistic regression model, accounting for hip side, individual and cohort-level variation.RESULTS: A total of 23 886 hips were included (mean age: 62.2±8.4 years; 70.6% female; BMI: 27.4±4.5; mean time to follow-up: 6.1±3.0 years). Cam morphology was associated with RHOA (OR: 1.87, 95% CI 1.36 to 2.59), as was a greater alpha angle (OR 1.02, 95% CI 1.01 to 1.03 for every degree increase). The overall relative risk of developing RHOA in hips with cam morphology was 1.62 (95%CI 1.26 to 2.07), greatest for those aged 51-60 years (2.15, 95% CI 1.55 to 2.98) and higher in males (2.50, 95% CI 1.67 to 3.73), compared with females (1.75,95% CI 1.24 to 2.48).CONCLUSION: Hips with cam morphology have higher odds of developing RHOA within 4-8 years compared with hips without cam morphology. The relative risk was highest in subgroups of participants aged 51-60 years and in males, making cam morphology a potential target for primary or secondary prevention of RHOA.
AB - OBJECTIVE: To assess the relationship between cam morphology and the development of radiographic hip osteoarthritis (RHOA), overall and in subgroups based on age, biological sex and body mass index (BMI).METHODS: Hips with no RHOA at baseline and with available follow-up during 4-8 years were selected from the Worldwide Collaboration on Osteoarthritis PrediCtion for the Hip (World COACH) consortium. Alpha angles were uniformly measured on anteroposterior radiographs, with a threshold of 60° used to define cam morphology. Incident RHOA was defined as the transition from an RHOA-free state at baseline to definite diagnosis of RHOA at follow-up. The association between baseline cam morphology and the development of RHOA was assessed using a three-level mixed-effects logistic regression model, accounting for hip side, individual and cohort-level variation.RESULTS: A total of 23 886 hips were included (mean age: 62.2±8.4 years; 70.6% female; BMI: 27.4±4.5; mean time to follow-up: 6.1±3.0 years). Cam morphology was associated with RHOA (OR: 1.87, 95% CI 1.36 to 2.59), as was a greater alpha angle (OR 1.02, 95% CI 1.01 to 1.03 for every degree increase). The overall relative risk of developing RHOA in hips with cam morphology was 1.62 (95%CI 1.26 to 2.07), greatest for those aged 51-60 years (2.15, 95% CI 1.55 to 2.98) and higher in males (2.50, 95% CI 1.67 to 3.73), compared with females (1.75,95% CI 1.24 to 2.48).CONCLUSION: Hips with cam morphology have higher odds of developing RHOA within 4-8 years compared with hips without cam morphology. The relative risk was highest in subgroups of participants aged 51-60 years and in males, making cam morphology a potential target for primary or secondary prevention of RHOA.
KW - Cohort Studies
KW - Hip
KW - Osteoarthritis
UR - https://www.scopus.com/pages/publications/105023642828
U2 - 10.1136/bjsports-2025-110144
DO - 10.1136/bjsports-2025-110144
M3 - Article
C2 - 41314784
SN - 0306-3674
VL - 60
SP - 28
EP - 35
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
M1 - bjsports-2025-110144
ER -