Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe

Konstantinos K Tsilidis; Nikos Papadimitriou; Despoina Capothanassi; Christina Bamia; Vassiliki Benetou; Mazda Jenab; Heinz Freisling; Frank Kee; Annemarie Nelen; Mark G O'Doherty; Angela Scott; Isabelle Soerjomataram; Anne Tjønneland; Anne M May; J Ramón Quirós; Ulrika Pettersson-Kymmer; Hermann Brenner; Ben Schöttker; José M Ordóñez-Mena; Aida Karina Dieffenbach; Sture Eriksson; Ellisiv Bøgeberg Mathiesen; Inger Njølstad; Galatios Siganos; Tom Wilsgaard; Paolo Boffetta; Dimitrios Trichopoulos; Antonia Trichopoulou

doi:10.1093/jnci/djw127

Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe

Konstantinos K Tsilidis, Nikos Papadimitriou, Despoina Capothanassi, Christina Bamia, Vassiliki Benetou, Mazda Jenab, Heinz Freisling, Frank Kee, Annemarie Nelen, Mark G O'Doherty, Angela Scott, Isabelle Soerjomataram, Anne Tjønneland, Anne M May, J Ramón Quirós, Ulrika Pettersson-Kymmer, Hermann Brenner, Ben Schöttker, José M Ordóñez-Mena, Aida Karina DieffenbachSture Eriksson, Ellisiv Bøgeberg Mathiesen, Inger Njølstad, Galatios Siganos, Tom Wilsgaard, Paolo Boffetta, Dimitrios Trichopoulos, Antonia Trichopoulou

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Disability-adjusted life-years (DALYs) are an indicator of mortality, morbidity, and disability. We calculated DALYs for cancer in middle-aged and older adults participating in the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) consortium.

METHODS: A total of 90 199 participants from five European cohorts with 10 455 incident cancers and 4399 deaths were included in this study. DALYs were calculated as the sum of the years of life lost because of premature mortality (YLLs) and the years lost because of disability (YLDs). Population-attributable fractions (PAFs) were also estimated for five cancer risk factors, ie, smoking, adiposity, physical inactivity, alcohol intake, and type II diabetes.

RESULTS: After a median follow-up of 12 years, the total number of DALYs lost from cancer was 34 474 (382 per 1000 individuals) with a similar distribution by sex. Lung cancer was responsible for the largest number of lost DALYs (22.9%), followed by colorectal (15.3%), prostate (10.2%), and breast cancer (8.7%). Mortality (81.6% of DALYs) predominated over disability. Ever cigarette smoking was the risk factor responsible for the greatest total cancer burden (24.0%, 95% confidence interval [CI] = 22.2% to 26.0%), followed by physical inactivity (4.9%, 95% CI = 0.8% to 8.1%) and adiposity (1.8%, 95% CI = 0.2% to 2.8%).

CONCLUSIONS: DALYs lost from cancer were substantial in this large European sample of middle-aged and older adults. Even if the burden of disease because of cancer is predominantly caused by mortality, some cancers have sizeable consequences for disability. Smoking remained the predominant risk factor for total cancer burden.

Original language	English
Article number	djw127
Journal	Journal of the National Cancer Institute
Volume	108
Issue number	10
DOIs	https://doi.org/10.1093/jnci/djw127
Publication status	Published - 2016

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Tsilidis, K. K., Papadimitriou, N., Capothanassi, D., Bamia, C., Benetou, V., Jenab, M., Freisling, H., Kee, F., Nelen, A., O'Doherty, M. G., Scott, A., Soerjomataram, I., Tjønneland, A., May, A. M., Ramón Quirós, J., Pettersson-Kymmer, U., Brenner, H., Schöttker, B., Ordóñez-Mena, J. M., ... Trichopoulou, A. (2016). Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe. Journal of the National Cancer Institute, 108(10), Article djw127. https://doi.org/10.1093/jnci/djw127

@article{f4cf71e3ec6a43ffbba6e2ca9b8c257a,

title = "Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe",

abstract = "BACKGROUND: Disability-adjusted life-years (DALYs) are an indicator of mortality, morbidity, and disability. We calculated DALYs for cancer in middle-aged and older adults participating in the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) consortium.METHODS: A total of 90 199 participants from five European cohorts with 10 455 incident cancers and 4399 deaths were included in this study. DALYs were calculated as the sum of the years of life lost because of premature mortality (YLLs) and the years lost because of disability (YLDs). Population-attributable fractions (PAFs) were also estimated for five cancer risk factors, ie, smoking, adiposity, physical inactivity, alcohol intake, and type II diabetes.RESULTS: After a median follow-up of 12 years, the total number of DALYs lost from cancer was 34 474 (382 per 1000 individuals) with a similar distribution by sex. Lung cancer was responsible for the largest number of lost DALYs (22.9%), followed by colorectal (15.3%), prostate (10.2%), and breast cancer (8.7%). Mortality (81.6% of DALYs) predominated over disability. Ever cigarette smoking was the risk factor responsible for the greatest total cancer burden (24.0%, 95% confidence interval [CI] = 22.2% to 26.0%), followed by physical inactivity (4.9%, 95% CI = 0.8% to 8.1%) and adiposity (1.8%, 95% CI = 0.2% to 2.8%).CONCLUSIONS: DALYs lost from cancer were substantial in this large European sample of middle-aged and older adults. Even if the burden of disease because of cancer is predominantly caused by mortality, some cancers have sizeable consequences for disability. Smoking remained the predominant risk factor for total cancer burden.",

author = "Tsilidis, {Konstantinos K} and Nikos Papadimitriou and Despoina Capothanassi and Christina Bamia and Vassiliki Benetou and Mazda Jenab and Heinz Freisling and Frank Kee and Annemarie Nelen and O'Doherty, {Mark G} and Angela Scott and Isabelle Soerjomataram and Anne Tj{\o}nneland and May, {Anne M} and {Ram{\'o}n Quir{\'o}s}, J and Ulrika Pettersson-Kymmer and Hermann Brenner and Ben Sch{\"o}ttker and Ord{\'o}{\~n}ez-Mena, {Jos{\'e} M} and {Karina Dieffenbach}, Aida and Sture Eriksson and {B{\o}geberg Mathiesen}, Ellisiv and Inger Nj{\o}lstad and Galatios Siganos and Tom Wilsgaard and Paolo Boffetta and Dimitrios Trichopoulos and Antonia Trichopoulou",

year = "2016",

doi = "10.1093/jnci/djw127",

language = "English",

volume = "108",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "10",

}

Tsilidis, KK, Papadimitriou, N, Capothanassi, D, Bamia, C, Benetou, V, Jenab, M, Freisling, H, Kee, F, Nelen, A, O'Doherty, MG, Scott, A, Soerjomataram, I, Tjønneland, A, May, AM, Ramón Quirós, J, Pettersson-Kymmer, U, Brenner, H, Schöttker, B, Ordóñez-Mena, JM, Karina Dieffenbach, A, Eriksson, S, Bøgeberg Mathiesen, E, Njølstad, I, Siganos, G, Wilsgaard, T, Boffetta, P, Trichopoulos, D & Trichopoulou, A 2016, 'Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe', Journal of the National Cancer Institute, vol. 108, no. 10, djw127. https://doi.org/10.1093/jnci/djw127

TY - JOUR

T1 - Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe

AU - Tsilidis, Konstantinos K

AU - Papadimitriou, Nikos

AU - Capothanassi, Despoina

AU - Bamia, Christina

AU - Benetou, Vassiliki

AU - Jenab, Mazda

AU - Freisling, Heinz

AU - Kee, Frank

AU - Nelen, Annemarie

AU - O'Doherty, Mark G

AU - Scott, Angela

AU - Soerjomataram, Isabelle

AU - Tjønneland, Anne

AU - May, Anne M

AU - Ramón Quirós, J

AU - Pettersson-Kymmer, Ulrika

AU - Brenner, Hermann

AU - Schöttker, Ben

AU - Ordóñez-Mena, José M

AU - Karina Dieffenbach, Aida

AU - Eriksson, Sture

AU - Bøgeberg Mathiesen, Ellisiv

AU - Njølstad, Inger

AU - Siganos, Galatios

AU - Wilsgaard, Tom

AU - Boffetta, Paolo

AU - Trichopoulos, Dimitrios

AU - Trichopoulou, Antonia

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Disability-adjusted life-years (DALYs) are an indicator of mortality, morbidity, and disability. We calculated DALYs for cancer in middle-aged and older adults participating in the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) consortium.METHODS: A total of 90 199 participants from five European cohorts with 10 455 incident cancers and 4399 deaths were included in this study. DALYs were calculated as the sum of the years of life lost because of premature mortality (YLLs) and the years lost because of disability (YLDs). Population-attributable fractions (PAFs) were also estimated for five cancer risk factors, ie, smoking, adiposity, physical inactivity, alcohol intake, and type II diabetes.RESULTS: After a median follow-up of 12 years, the total number of DALYs lost from cancer was 34 474 (382 per 1000 individuals) with a similar distribution by sex. Lung cancer was responsible for the largest number of lost DALYs (22.9%), followed by colorectal (15.3%), prostate (10.2%), and breast cancer (8.7%). Mortality (81.6% of DALYs) predominated over disability. Ever cigarette smoking was the risk factor responsible for the greatest total cancer burden (24.0%, 95% confidence interval [CI] = 22.2% to 26.0%), followed by physical inactivity (4.9%, 95% CI = 0.8% to 8.1%) and adiposity (1.8%, 95% CI = 0.2% to 2.8%).CONCLUSIONS: DALYs lost from cancer were substantial in this large European sample of middle-aged and older adults. Even if the burden of disease because of cancer is predominantly caused by mortality, some cancers have sizeable consequences for disability. Smoking remained the predominant risk factor for total cancer burden.

AB - BACKGROUND: Disability-adjusted life-years (DALYs) are an indicator of mortality, morbidity, and disability. We calculated DALYs for cancer in middle-aged and older adults participating in the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) consortium.METHODS: A total of 90 199 participants from five European cohorts with 10 455 incident cancers and 4399 deaths were included in this study. DALYs were calculated as the sum of the years of life lost because of premature mortality (YLLs) and the years lost because of disability (YLDs). Population-attributable fractions (PAFs) were also estimated for five cancer risk factors, ie, smoking, adiposity, physical inactivity, alcohol intake, and type II diabetes.RESULTS: After a median follow-up of 12 years, the total number of DALYs lost from cancer was 34 474 (382 per 1000 individuals) with a similar distribution by sex. Lung cancer was responsible for the largest number of lost DALYs (22.9%), followed by colorectal (15.3%), prostate (10.2%), and breast cancer (8.7%). Mortality (81.6% of DALYs) predominated over disability. Ever cigarette smoking was the risk factor responsible for the greatest total cancer burden (24.0%, 95% confidence interval [CI] = 22.2% to 26.0%), followed by physical inactivity (4.9%, 95% CI = 0.8% to 8.1%) and adiposity (1.8%, 95% CI = 0.2% to 2.8%).CONCLUSIONS: DALYs lost from cancer were substantial in this large European sample of middle-aged and older adults. Even if the burden of disease because of cancer is predominantly caused by mortality, some cancers have sizeable consequences for disability. Smoking remained the predominant risk factor for total cancer burden.

U2 - 10.1093/jnci/djw127

DO - 10.1093/jnci/djw127

M3 - Article

C2 - 27154917

SN - 0027-8874

VL - 108

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 10

M1 - djw127

ER -

Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe

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