@article{341705ba047744098b2d5181939f925e,
title = "Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids",
abstract = "Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.",
keywords = "bile duct, Delphi method, epithelial organoid, gallbladder, HPB, liver, multi-organ organoid, multi-tissue organoid, pancreas, tumor organoid",
author = "Ary Marsee and Roos, {Floris J.M.} and Verstegen, {Monique M.A.} and Floris Roos and Monique Verstegen and Hans Clevers and Ludovic Vallier and Takanori Takebe and Meritxell Huch and Peng, {Weng Chuan} and Stuart Forbes and Fr{\'e}d{\'e}ric Lemaigre and {de Koning}, Eelco and Helmuth Gehart and {van der Laan}, Luc and Bart Spee and Sylvia Boj and Pedro Baptista and Kerstin Schneeberger and Carol Soroka and Markus Heim and Sandro Nuciforo and Kenneth Zaret and Yoshimasa Saito and Matthias Lutolf and Vincenzo Cardinale and Ben Simons and {van IJzendoorn}, Sven and Akihide Kamiya and Hiromi Chikada and Shuyong Wang and Mun, {Seon Ju} and Son, {Myung Jin} and Onder, {Tamer Tevfik} and James Boyer and Toshiro Sato and Nikitas Georgakopoulos and Andre Meneses and Laura Broutier and Luke Boulter and Dominic Gr{\"u}n and Jan IJzermans and Benedetta Artegiani and {van Boxtel}, Ruben and Ewart Kuijk and Guido Carpino and Gary Peltz and Jesus Banales and Nancy Man and Sabine Fuchs",
note = "Funding Information: The L.J.W.v.d.L. lab is supported by the MLDS-Diagnostiek grant D16-26 of the Dutch Gastroenterology & Hepatology Fund (MLDS) and the Medical Delta Regenerative Medicine 4D program. The B.S. lab is supported by the European Union{\textquoteright}s Horizon 2020 research and innovation program under grant agreement no. 874586 . The L.V. lab is funded by the ERC advanced grant New-Chol, the Cambridge University Hospitals National Institute for Health Research Biomedical Research Centre, and the core support grant from the Wellcome and Medical Research Council Cambridge Stem Cell Institute. The M.H. lab is funded by a Lise Meitner Excellence Program award from the Max Planck Society. For a detailed breakdown of the additional affiliations, locations, and roles of each HPB Organoid Consortium member, see Table S1 . Funding Information: The L.J.W.v.d.L. lab is supported by the MLDS-Diagnostiek grant D16-26 of the Dutch Gastroenterology & Hepatology Fund (MLDS) and the Medical Delta Regenerative Medicine 4D program. The B.S. lab is supported by the European Union's Horizon 2020 research and innovation program under grant agreement no. 874586. The L.V. lab is funded by the ERC advanced grant New-Chol, the Cambridge University Hospitals National Institute for Health Research Biomedical Research Centre, and the core support grant from the Wellcome and Medical Research Council Cambridge Stem Cell Institute. The M.H. lab is funded by a Lise Meitner Excellence Program award from the Max Planck Society. For a detailed breakdown of the additional affiliations, locations, and roles of each HPB Organoid Consortium member, see Table S1. A.M. and F.J.M.R. drafted the manuscript, designed the questionnaires, and contacted all experts from the HPB organoid consortium. A.M. F.J.M.R. M.M.A.V. H.G. E.d.K. F.L. S.J.F. W.C.P. M.H. T.T. L.V. H.C. L.J.W.v.d.L. and B.S. discussed questionnaire results and provided recommendations. All authors discussed the results and contributed to the final manuscript. H.G. M.H. T.T. L.V. and H.C. are inventors on several patents related to organoid technology. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = may,
day = "6",
doi = "10.1016/j.stem.2021.04.005",
language = "English",
volume = "28",
pages = "816--832",
journal = "Cell stem cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "5",
}