Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study

Welmoed A Krudop; Cora J Kerssens; Annemieke Dols; Niels D Prins; Christiane Möller; Sigfried Schouws; Frederik Barkhof; Bart N M van Berckel; Charlotte E Teunissen; Wiesje M van der Flier; Philip Scheltens; Max L Stek; Yolande A L Pijnenburg

doi:10.1016/j.jagp.2013.02.002

Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study

Welmoed A Krudop
, Cora J Kerssens
, Annemieke Dols
, Niels D Prins
, Christiane Möller
, Sigfried Schouws
, Frederik Barkhof
, Bart N M van Berckel
, Charlotte E Teunissen
, Wiesje M van der Flier
, Philip Scheltens
, Max L Stek
, Yolande A L Pijnenburg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.

METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.

RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.

CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

Original language	English
Pages (from-to)	735-40
Number of pages	6
Journal	The American Journal of Geriatric Psychiatry
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/j.jagp.2013.02.002
Publication status	Published - Jul 2014

Keywords

Age of Onset
Aged
Amyloid beta-Peptides/cerebrospinal fluid
Biomarkers/cerebrospinal fluid
Clinical Protocols
Cross-Sectional Studies
Diagnosis, Differential
Early Diagnosis
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Frontotemporal Dementia/cerebrospinal fluid
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography
Predictive Value of Tests
Prospective Studies
tau Proteins/cerebrospinal fluid

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10.1016/j.jagp.2013.02.002

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Krudop, W. A., Kerssens, C. J., Dols, A., Prins, N. D., Möller, C., Schouws, S., Barkhof, F., van Berckel, B. N. M., Teunissen, C. E., van der Flier, W. M., Scheltens, P., Stek, M. L., & Pijnenburg, Y. A. L. (2014). Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study. The American Journal of Geriatric Psychiatry, 22(7), 735-40. https://doi.org/10.1016/j.jagp.2013.02.002

@article{487660dc84084e1b9ca48c357197e63a,

title = "Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study",

abstract = "OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.",

keywords = "Age of Onset, Aged, Amyloid beta-Peptides/cerebrospinal fluid, Biomarkers/cerebrospinal fluid, Clinical Protocols, Cross-Sectional Studies, Diagnosis, Differential, Early Diagnosis, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Frontotemporal Dementia/cerebrospinal fluid, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Predictive Value of Tests, Prospective Studies, tau Proteins/cerebrospinal fluid",

author = "Krudop, \{Welmoed A\} and Kerssens, \{Cora J\} and Annemieke Dols and Prins, \{Niels D\} and Christiane M{\"o}ller and Sigfried Schouws and Frederik Barkhof and \{van Berckel\}, \{Bart N M\} and Teunissen, \{Charlotte E\} and \{van der Flier\}, \{Wiesje M\} and Philip Scheltens and Stek, \{Max L\} and Pijnenburg, \{Yolande A L\}",

year = "2014",

month = jul,

doi = "10.1016/j.jagp.2013.02.002",

language = "English",

volume = "22",

pages = "735--40",

journal = "The American Journal of Geriatric Psychiatry",

issn = "1064-7481",

publisher = "Elsevier",

number = "7",

}

Krudop, WA, Kerssens, CJ, Dols, A, Prins, ND, Möller, C, Schouws, S, Barkhof, F, van Berckel, BNM, Teunissen, CE, van der Flier, WM, Scheltens, P, Stek, ML & Pijnenburg, YAL 2014, 'Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study', The American Journal of Geriatric Psychiatry, vol. 22, no. 7, pp. 735-40. https://doi.org/10.1016/j.jagp.2013.02.002

TY - JOUR

T1 - Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia

T2 - Late Onset Frontal Lobe Syndrome study

AU - Krudop, Welmoed A

AU - Kerssens, Cora J

AU - Dols, Annemieke

AU - Prins, Niels D

AU - Möller, Christiane

AU - Schouws, Sigfried

AU - Barkhof, Frederik

AU - van Berckel, Bart N M

AU - Teunissen, Charlotte E

AU - van der Flier, Wiesje M

AU - Scheltens, Philip

AU - Stek, Max L

AU - Pijnenburg, Yolande A L

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

AB - OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

KW - Age of Onset

KW - Aged

KW - Amyloid beta-Peptides/cerebrospinal fluid

KW - Biomarkers/cerebrospinal fluid

KW - Clinical Protocols

KW - Cross-Sectional Studies

KW - Diagnosis, Differential

KW - Early Diagnosis

KW - Female

KW - Fluorodeoxyglucose F18

KW - Follow-Up Studies

KW - Frontotemporal Dementia/cerebrospinal fluid

KW - Functional Neuroimaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Positron-Emission Tomography

KW - Predictive Value of Tests

KW - Prospective Studies

KW - tau Proteins/cerebrospinal fluid

U2 - 10.1016/j.jagp.2013.02.002

DO - 10.1016/j.jagp.2013.02.002

M3 - Article

C2 - 23806681

SN - 1064-7481

VL - 22

SP - 735

EP - 740

JO - The American Journal of Geriatric Psychiatry

JF - The American Journal of Geriatric Psychiatry

IS - 7

ER -

Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study

Abstract

Keywords

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