Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study

Welmoed A Krudop; Cora J Kerssens; Annemieke Dols; Niels D Prins; Christiane Möller; Sigfried Schouws; Frederik Barkhof; Bart N M van Berckel; Charlotte E Teunissen; Wiesje M van der Flier; Philip Scheltens; Max L Stek; Yolande A L Pijnenburg

doi:10.1016/j.jagp.2013.02.002

Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study

Welmoed A Krudop, Cora J Kerssens, Annemieke Dols, Niels D Prins, Christiane Möller, Sigfried Schouws, Frederik Barkhof, Bart N M van Berckel, Charlotte E Teunissen, Wiesje M van der Flier, Philip Scheltens, Max L Stek, Yolande A L Pijnenburg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.

METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.

RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.

CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

Original language	English
Pages (from-to)	735-40
Number of pages	6
Journal	The American Journal of Geriatric Psychiatry
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/j.jagp.2013.02.002
Publication status	Published - Jul 2014

Keywords

Age of Onset
Aged
Amyloid beta-Peptides/cerebrospinal fluid
Biomarkers/cerebrospinal fluid
Clinical Protocols
Cross-Sectional Studies
Diagnosis, Differential
Early Diagnosis
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Frontotemporal Dementia/cerebrospinal fluid
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography
Predictive Value of Tests
Prospective Studies
tau Proteins/cerebrospinal fluid

Access to Document

10.1016/j.jagp.2013.02.002

Cite this

Krudop, W. A., Kerssens, C. J., Dols, A., Prins, N. D., Möller, C., Schouws, S., Barkhof, F., van Berckel, B. N. M., Teunissen, C. E., van der Flier, W. M., Scheltens, P., Stek, M. L., & Pijnenburg, Y. A. L. (2014). Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study. The American Journal of Geriatric Psychiatry, 22(7), 735-40. https://doi.org/10.1016/j.jagp.2013.02.002

@article{487660dc84084e1b9ca48c357197e63a,

title = "Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study",

abstract = "OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.",

keywords = "Age of Onset, Aged, Amyloid beta-Peptides/cerebrospinal fluid, Biomarkers/cerebrospinal fluid, Clinical Protocols, Cross-Sectional Studies, Diagnosis, Differential, Early Diagnosis, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Frontotemporal Dementia/cerebrospinal fluid, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Predictive Value of Tests, Prospective Studies, tau Proteins/cerebrospinal fluid",

author = "Krudop, {Welmoed A} and Kerssens, {Cora J} and Annemieke Dols and Prins, {Niels D} and Christiane M{\"o}ller and Sigfried Schouws and Frederik Barkhof and {van Berckel}, {Bart N M} and Teunissen, {Charlotte E} and {van der Flier}, {Wiesje M} and Philip Scheltens and Stek, {Max L} and Pijnenburg, {Yolande A L}",

year = "2014",

month = jul,

doi = "10.1016/j.jagp.2013.02.002",

language = "English",

volume = "22",

pages = "735--40",

journal = "The American Journal of Geriatric Psychiatry",

issn = "1064-7481",

publisher = "Lippincott Williams & Wilkins",

number = "7",

}

Krudop, WA, Kerssens, CJ, Dols, A, Prins, ND, Möller, C, Schouws, S, Barkhof, F, van Berckel, BNM, Teunissen, CE, van der Flier, WM, Scheltens, P, Stek, ML & Pijnenburg, YAL 2014, 'Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study', The American Journal of Geriatric Psychiatry, vol. 22, no. 7, pp. 735-40. https://doi.org/10.1016/j.jagp.2013.02.002

TY - JOUR

T1 - Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia

T2 - Late Onset Frontal Lobe Syndrome study

AU - Krudop, Welmoed A

AU - Kerssens, Cora J

AU - Dols, Annemieke

AU - Prins, Niels D

AU - Möller, Christiane

AU - Schouws, Sigfried

AU - Barkhof, Frederik

AU - van Berckel, Bart N M

AU - Teunissen, Charlotte E

AU - van der Flier, Wiesje M

AU - Scheltens, Philip

AU - Stek, Max L

AU - Pijnenburg, Yolande A L

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

AB - OBJECTIVE: To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.METHODS: The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.RESULTS: The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.CONCLUSION: This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

KW - Age of Onset

KW - Aged

KW - Amyloid beta-Peptides/cerebrospinal fluid

KW - Biomarkers/cerebrospinal fluid

KW - Clinical Protocols

KW - Cross-Sectional Studies

KW - Diagnosis, Differential

KW - Early Diagnosis

KW - Female

KW - Fluorodeoxyglucose F18

KW - Follow-Up Studies

KW - Frontotemporal Dementia/cerebrospinal fluid

KW - Functional Neuroimaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Positron-Emission Tomography

KW - Predictive Value of Tests

KW - Prospective Studies

KW - tau Proteins/cerebrospinal fluid

U2 - 10.1016/j.jagp.2013.02.002

DO - 10.1016/j.jagp.2013.02.002

M3 - Article

C2 - 23806681

SN - 1064-7481

VL - 22

SP - 735

EP - 740

JO - The American Journal of Geriatric Psychiatry

JF - The American Journal of Geriatric Psychiatry

IS - 7

ER -

Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study

Abstract

Keywords

Access to Document

Fingerprint

Cite this