Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)

Wouter G. Staal; Mariken de Krom; Maretha V. de Jonge

doi:10.1007/s10803-011-1312-z

Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)

Wouter G. Staal^*, Mariken de Krom, Maretha V. de Jonge

^*Corresponding author for this work

Psychiatry

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor "insistence on sameness" (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing.

Original language	English
Pages (from-to)	885-888
Number of pages	4
Journal	Journal of Autism and Developmental Disorders
Volume	42
Issue number	5
DOIs	https://doi.org/10.1007/s10803-011-1312-z
Publication status	Published - May 2012

Keywords

DRD3
rs167771
Autism
Stereotyped behavior
EFFICACY

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10.1007/s10803-011-1312-z

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title = "Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)",

abstract = "Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor {"}insistence on sameness{"} (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing.",

keywords = "DRD3, rs167771, Autism, Stereotyped behavior, EFFICACY",

author = "Staal, {Wouter G.} and {de Krom}, Mariken and {de Jonge}, {Maretha V.}",

year = "2012",

month = may,

doi = "10.1007/s10803-011-1312-z",

language = "English",

volume = "42",

pages = "885--888",

journal = "Journal of Autism and Developmental Disorders",

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T2 - The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)

AU - Staal, Wouter G.

AU - de Krom, Mariken

AU - de Jonge, Maretha V.

PY - 2012/5

Y1 - 2012/5

N2 - Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor "insistence on sameness" (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing.

AB - Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor "insistence on sameness" (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing.

KW - DRD3

KW - rs167771

KW - Autism

KW - Stereotyped behavior

KW - EFFICACY

U2 - 10.1007/s10803-011-1312-z

DO - 10.1007/s10803-011-1312-z

M3 - Article

C2 - 21691864

SN - 0162-3257

VL - 42

SP - 885

EP - 888

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 5

ER -

Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)

Abstract

Keywords

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