TY - JOUR
T1 - Breath Test
T2 - Clinical Application of Breath Analysis in Lower Respiratory Tract Infection Diagnosis
AU - Van Aerde, Koen J.
AU - Jansen, Robin
AU - Merkus, Peter J.
AU - Van Der Flier, Michiel
N1 - Funding Information:
This work was supported by European Union? s Horizon 2020, project PERFORM, grant agreement No. 668303 and an ESPID fellowship grant to K.J.v.A.
Funding Information:
This work was supported by European Union’s Horizon 2020, project PERFORM, grant agreement No. 668303 and an ESPID fellowship grant to K.J.v.A.
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Breath research shows promise in diagnosing LRTIs with various etiology and is feasible both in children and in adults. In general, combinations of several biomarkers in a VOC profile or E-nose breathprints demonstrate the best sensitivity and specificity. At this moment, breath analysis can be of value as a screening tool. The time is ready for larger scale validation studies, including pediatric patients and using appropriate control groups, to further establish the accuracy of breath analysis in diagnosing etiology of LRTIs, and the potential to replace the current more invasive diagnostic methods.
AB - Breath research shows promise in diagnosing LRTIs with various etiology and is feasible both in children and in adults. In general, combinations of several biomarkers in a VOC profile or E-nose breathprints demonstrate the best sensitivity and specificity. At this moment, breath analysis can be of value as a screening tool. The time is ready for larger scale validation studies, including pediatric patients and using appropriate control groups, to further establish the accuracy of breath analysis in diagnosing etiology of LRTIs, and the potential to replace the current more invasive diagnostic methods.
UR - http://www.scopus.com/inward/record.url?scp=85117435497&partnerID=8YFLogxK
U2 - 10.1097/INF.0000000000003310
DO - 10.1097/INF.0000000000003310
M3 - Review article
C2 - 34591801
AN - SCOPUS:85117435497
SN - 0891-3668
VL - 40
SP - E434-E436
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 11
ER -