Brain Volumes at Term-Equivalent Age in Preterm Infants: Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age

Kristin Keunen; Ivana Išgum; Britt J M van Kooij; Petronella Anbeek; Ingrid C van Haastert; Corine Koopman-Esseboom; Petronella C van Stam; Rutger A J Nievelstein; Max A Viergever; Linda S de Vries; Floris Groenendaal; Manon J N L Benders

doi:10.1016/j.jpeds.2015.12.023

Brain Volumes at Term-Equivalent Age in Preterm Infants: Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age

Kristin Keunen, Ivana Išgum, Britt J M van Kooij, Petronella Anbeek, Ingrid C van Haastert, Corine Koopman-Esseboom, Petronella C van Stam, Rutger A J Nievelstein, Max A Viergever, Linda S de Vries, Floris Groenendaal, Manon J N L Benders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To evaluate the relationship between brain volumes at term and neurodevelopmental outcome through early school age in preterm infants.

STUDY DESIGN: One hundred twelve preterm infants (born mean gestational age 28.6 ± 1.7 weeks) were studied prospectively with magnetic resonance imaging (imaged at mean 41.6 ± 1.0 weeks). T2- and T1-weighted images were automatically segmented, and volumes of 6 tissue types were related to neurodevelopmental outcome assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (cognitive, fine, and gross motor scores) at 24 months corrected age (n = 112), Griffiths Mental Development Scales (developmental quotient) at age 3.5 years (n = 98), Movement Assessment Battery for Children, Second Edition (n = 85), and Wechsler Preschool and Primary Scale of Intelligence, Third Edition at age 5.5 years (n = 44). Corrections were made for intracranial volume, maternal education, and severe brain lesions.

RESULTS: Ventricular volumes were negatively related to neurodevelopmental outcome at age 24 months and 3.5 years, as well as processing speed at age 5.5 years. Unmyelinated white matter (UWM) volume was positively associated with motor outcome at 24 months and with processing speed at age 5.5 years. Cortical gray matter (CGM) volume demonstrated a negative association with motor performance and cognition at 24 months and with developmental quotient at age 3.5 years. Cerebellar volume was positively related to cognition at these time points. Adjustment for brain lesions attenuated the relations between cerebellar and CGM volumes and cognition.

CONCLUSIONS: Brain volumes of ventricles, UWM, CGM, and cerebellum may serve as biomarkers for neurodevelopmental outcome in preterm infants. The relationship between larger CGM volumes and adverse neurodevelopment may reflect disturbances in neuronal and/or axonal migration at the UWM-CGM boundary and warrants further investigation.

Original language	English
Pages (from-to)	88-95
Journal	Journal of Pediatrics
Volume	172
DOIs	https://doi.org/10.1016/j.jpeds.2015.12.023
Publication status	Published - May 2016

Access to Document

10.1016/j.jpeds.2015.12.023

Cite this

Keunen, K., Išgum, I., van Kooij, B. J. M., Anbeek, P., van Haastert, I. C., Koopman-Esseboom, C., van Stam, P. C., Nievelstein, R. A. J., Viergever, M. A., de Vries, L. S., Groenendaal, F., & Benders, M. J. N. L. (2016). Brain Volumes at Term-Equivalent Age in Preterm Infants: Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age. Journal of Pediatrics, 172, 88-95. https://doi.org/10.1016/j.jpeds.2015.12.023

@article{f0b647cf2e8047828b7b35995567513a,

title = "Brain Volumes at Term-Equivalent Age in Preterm Infants: Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age",

abstract = "OBJECTIVE: To evaluate the relationship between brain volumes at term and neurodevelopmental outcome through early school age in preterm infants.STUDY DESIGN: One hundred twelve preterm infants (born mean gestational age 28.6 ± 1.7 weeks) were studied prospectively with magnetic resonance imaging (imaged at mean 41.6 ± 1.0 weeks). T2- and T1-weighted images were automatically segmented, and volumes of 6 tissue types were related to neurodevelopmental outcome assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (cognitive, fine, and gross motor scores) at 24 months corrected age (n = 112), Griffiths Mental Development Scales (developmental quotient) at age 3.5 years (n = 98), Movement Assessment Battery for Children, Second Edition (n = 85), and Wechsler Preschool and Primary Scale of Intelligence, Third Edition at age 5.5 years (n = 44). Corrections were made for intracranial volume, maternal education, and severe brain lesions.RESULTS: Ventricular volumes were negatively related to neurodevelopmental outcome at age 24 months and 3.5 years, as well as processing speed at age 5.5 years. Unmyelinated white matter (UWM) volume was positively associated with motor outcome at 24 months and with processing speed at age 5.5 years. Cortical gray matter (CGM) volume demonstrated a negative association with motor performance and cognition at 24 months and with developmental quotient at age 3.5 years. Cerebellar volume was positively related to cognition at these time points. Adjustment for brain lesions attenuated the relations between cerebellar and CGM volumes and cognition.CONCLUSIONS: Brain volumes of ventricles, UWM, CGM, and cerebellum may serve as biomarkers for neurodevelopmental outcome in preterm infants. The relationship between larger CGM volumes and adverse neurodevelopment may reflect disturbances in neuronal and/or axonal migration at the UWM-CGM boundary and warrants further investigation.",

author = "Kristin Keunen and Ivana I{\v s}gum and {van Kooij}, {Britt J M} and Petronella Anbeek and {van Haastert}, {Ingrid C} and Corine Koopman-Esseboom and {van Stam}, {Petronella C} and Nievelstein, {Rutger A J} and Viergever, {Max A} and {de Vries}, {Linda S} and Floris Groenendaal and Benders, {Manon J N L}",

year = "2016",

month = may,

doi = "10.1016/j.jpeds.2015.12.023",

language = "English",

volume = "172",

pages = "88--95",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

}

Keunen, K, Išgum, I, van Kooij, BJM, Anbeek, P, van Haastert, IC, Koopman-Esseboom, C, van Stam, PC, Nievelstein, RAJ , Viergever, MA , de Vries, LS , Groenendaal, F & Benders, MJNL 2016, 'Brain Volumes at Term-Equivalent Age in Preterm Infants: Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age', Journal of Pediatrics, vol. 172, pp. 88-95. https://doi.org/10.1016/j.jpeds.2015.12.023

TY - JOUR

T1 - Brain Volumes at Term-Equivalent Age in Preterm Infants

T2 - Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age

AU - Keunen, Kristin

AU - Išgum, Ivana

AU - van Kooij, Britt J M

AU - Anbeek, Petronella

AU - van Haastert, Ingrid C

AU - Koopman-Esseboom, Corine

AU - van Stam, Petronella C

AU - Nievelstein, Rutger A J

AU - Viergever, Max A

AU - de Vries, Linda S

AU - Groenendaal, Floris

AU - Benders, Manon J N L

PY - 2016/5

Y1 - 2016/5

N2 - OBJECTIVE: To evaluate the relationship between brain volumes at term and neurodevelopmental outcome through early school age in preterm infants.STUDY DESIGN: One hundred twelve preterm infants (born mean gestational age 28.6 ± 1.7 weeks) were studied prospectively with magnetic resonance imaging (imaged at mean 41.6 ± 1.0 weeks). T2- and T1-weighted images were automatically segmented, and volumes of 6 tissue types were related to neurodevelopmental outcome assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (cognitive, fine, and gross motor scores) at 24 months corrected age (n = 112), Griffiths Mental Development Scales (developmental quotient) at age 3.5 years (n = 98), Movement Assessment Battery for Children, Second Edition (n = 85), and Wechsler Preschool and Primary Scale of Intelligence, Third Edition at age 5.5 years (n = 44). Corrections were made for intracranial volume, maternal education, and severe brain lesions.RESULTS: Ventricular volumes were negatively related to neurodevelopmental outcome at age 24 months and 3.5 years, as well as processing speed at age 5.5 years. Unmyelinated white matter (UWM) volume was positively associated with motor outcome at 24 months and with processing speed at age 5.5 years. Cortical gray matter (CGM) volume demonstrated a negative association with motor performance and cognition at 24 months and with developmental quotient at age 3.5 years. Cerebellar volume was positively related to cognition at these time points. Adjustment for brain lesions attenuated the relations between cerebellar and CGM volumes and cognition.CONCLUSIONS: Brain volumes of ventricles, UWM, CGM, and cerebellum may serve as biomarkers for neurodevelopmental outcome in preterm infants. The relationship between larger CGM volumes and adverse neurodevelopment may reflect disturbances in neuronal and/or axonal migration at the UWM-CGM boundary and warrants further investigation.

AB - OBJECTIVE: To evaluate the relationship between brain volumes at term and neurodevelopmental outcome through early school age in preterm infants.STUDY DESIGN: One hundred twelve preterm infants (born mean gestational age 28.6 ± 1.7 weeks) were studied prospectively with magnetic resonance imaging (imaged at mean 41.6 ± 1.0 weeks). T2- and T1-weighted images were automatically segmented, and volumes of 6 tissue types were related to neurodevelopmental outcome assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (cognitive, fine, and gross motor scores) at 24 months corrected age (n = 112), Griffiths Mental Development Scales (developmental quotient) at age 3.5 years (n = 98), Movement Assessment Battery for Children, Second Edition (n = 85), and Wechsler Preschool and Primary Scale of Intelligence, Third Edition at age 5.5 years (n = 44). Corrections were made for intracranial volume, maternal education, and severe brain lesions.RESULTS: Ventricular volumes were negatively related to neurodevelopmental outcome at age 24 months and 3.5 years, as well as processing speed at age 5.5 years. Unmyelinated white matter (UWM) volume was positively associated with motor outcome at 24 months and with processing speed at age 5.5 years. Cortical gray matter (CGM) volume demonstrated a negative association with motor performance and cognition at 24 months and with developmental quotient at age 3.5 years. Cerebellar volume was positively related to cognition at these time points. Adjustment for brain lesions attenuated the relations between cerebellar and CGM volumes and cognition.CONCLUSIONS: Brain volumes of ventricles, UWM, CGM, and cerebellum may serve as biomarkers for neurodevelopmental outcome in preterm infants. The relationship between larger CGM volumes and adverse neurodevelopment may reflect disturbances in neuronal and/or axonal migration at the UWM-CGM boundary and warrants further investigation.

UR - http://www.scopus.com/inward/record.url?scp=84953431740&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2015.12.023

DO - 10.1016/j.jpeds.2015.12.023

M3 - Article

C2 - 26774198

AN - SCOPUS:84953431740

SN - 0022-3476

VL - 172

SP - 88

EP - 95

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Brain Volumes at Term-Equivalent Age in Preterm Infants: Imaging Biomarkers for Neurodevelopmental Outcome through Early School Age

Abstract

Access to Document

Other files and links

Fingerprint

Cite this