Brain Deep Medullary Veins on 7T MRI in Dutch-Type Hereditary Cerebral Amyloid Angiopathy

Thijs W. van Harten, Anne Heijmans, Sanneke van Rooden, Marieke J.H. Wermer, Matthias J.P. van Osch, Hugo J. Kuijf, Susannne van Veluw, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Marianne A.A. van Walderveen

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Abstract

BACKGROUND: Deep medullary vein (DMV) changes occur in cerebral small vessel diseases (SVD) and in Alzheimer's disease. Cerebral amyloid angiopathy (CAA) is a common SVD that has a high co-morbidity with Alzheimer's disease. So far, DMVs have not been evaluated in CAA. OBJECTIVE: To evaluate DMVs in Dutch-type hereditary CAA (D-CAA) mutation carriers and controls, in relation to MRI markers associated with D-CAA. METHODS: Quantitative DMV parameters length, tortuosity, inhomogeneity, and density were quantified on 7 Tesla 3D susceptibility weighted MRI in pre-symptomatic D-CAA mutation carriers (n = 8), symptomatic D-CAA mutation carriers (n = 8), and controls (n = 25). Hemorrhagic MRI markers (cerebral microbleeds, intracerebral hemorrhages, cortical superficial siderosis, convexity subarachnoid hemorrhage), non-hemorrhagic MRI markers (white matter hyperintensities, enlarged perivascular spaces, lacunar infarcts, cortical microinfarcts), cortical grey matter perfusion, and diffusion tensor imaging parameters were assessed in D-CAA mutation carriers. Univariate general linear analysis was used to determine associations between DMV parameters and MRI markers. RESULTS: Quantitative DMV parameters length, tortuosity, inhomogeneity, and density did not differ between pre-symptomatic D-CAA mutation carriers, symptomatic D-CAA mutation carriers, and controls. No associations were found between DMV parameters and MRI markers associated with D-CAA. CONCLUSION: This study indicates that vascular amyloid-β deposition does not affect DMV parameters. In patients with CAA, DMVs do not seem to play a role in the pathogenesis of MRI markers associated with CAA.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalJournal of Alzheimer's disease : JAD
Volume90
Issue number1
DOIs
Publication statusPublished - 25 Oct 2022

Keywords

  • Cerebral small vessel disease
  • cerebral veins
  • hereditary cerebral amyloid angiopathy
  • magnetic resonance imaging
  • Brain/diagnostic imaging
  • Cerebral Amyloid Angiopathy/diagnostic imaging
  • Humans
  • Cerebral Hemorrhage/diagnostic imaging
  • Cerebral Amyloid Angiopathy, Familial/diagnostic imaging
  • Magnetic Resonance Imaging/methods
  • Alzheimer Disease/complications
  • Diffusion Tensor Imaging

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