TY - JOUR
T1 - Brachytherapy for rhabdomyosarcoma
T2 - Survey of international clinical practice and development of guidelines
AU - Dávila Fajardo, Raquel
AU - Scarzello, Giovanni
AU - Gaze, Mark N
AU - Boterberg, Tom
AU - Cameron, Alison
AU - Fuchs, Joerg
AU - Guérin, Florent
AU - Hoskin, Peter
AU - Krasin, Matthew J
AU - Kroon, Petra
AU - Magelssen, Henriette
AU - Mercke, Claes
AU - Merks, Johannes H M
AU - Paulsen, Frank
AU - Pommier, Pascal
AU - Ramos, Monica
AU - Rees, Helen
AU - Rogers, Tim
AU - Schmid, Maximilian
AU - Seitz, Guido
AU - Slater, Olga
AU - Smeulders, Naima
AU - Stenman, Jakob
AU - Terwisscha, Sheila
AU - Chargari, Cyrus
AU - Mandeville, Henry C
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/6
Y1 - 2024/6
N2 - BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus guidelines.MATERIALS AND METHODS: An international expert panel on the treatment of pediatric rhabdomyosarcoma comprising 24 (pediatric) radiation oncologists, brachytherapists and pediatric surgeons met for a Brachytherapy Workshop hosted by the European paediatric Soft tissue Sarcoma Study Group (EpSSG). The panel's clinical experience, the results of a previously distributed questionnaire, and a review of the literature were presented.RESULTS: The survey indicated the most common use of brachytherapy to be in combination with tumor resection, followed by brachytherapy as sole local therapy modality. HDR was increasingly deployed in pediatric practice, especially for genitourinary sites. Brachytherapy planning was mostly by 3D imaging based on CT. Recommendations for patient selection, treatment requirements, implant technique, delineation, dose prescription, dose reporting and clinical management were defined.CONCLUSIONS: Consensus guidelines for the use of brachytherapy in pediatric rhabdomyosarcoma have been developed through multicenter collaboration establishing the basis for future work. These have been adopted for the open EpSSG overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma (FaR-RMS).
AB - BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus guidelines.MATERIALS AND METHODS: An international expert panel on the treatment of pediatric rhabdomyosarcoma comprising 24 (pediatric) radiation oncologists, brachytherapists and pediatric surgeons met for a Brachytherapy Workshop hosted by the European paediatric Soft tissue Sarcoma Study Group (EpSSG). The panel's clinical experience, the results of a previously distributed questionnaire, and a review of the literature were presented.RESULTS: The survey indicated the most common use of brachytherapy to be in combination with tumor resection, followed by brachytherapy as sole local therapy modality. HDR was increasingly deployed in pediatric practice, especially for genitourinary sites. Brachytherapy planning was mostly by 3D imaging based on CT. Recommendations for patient selection, treatment requirements, implant technique, delineation, dose prescription, dose reporting and clinical management were defined.CONCLUSIONS: Consensus guidelines for the use of brachytherapy in pediatric rhabdomyosarcoma have been developed through multicenter collaboration establishing the basis for future work. These have been adopted for the open EpSSG overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma (FaR-RMS).
KW - Rhabdomyosarcoma
KW - Soft Tissue Sarcoma
KW - Brachytherapy
UR - http://www.scopus.com/inward/record.url?scp=85190604394&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2024.110273
DO - 10.1016/j.radonc.2024.110273
M3 - Article
C2 - 38588921
SN - 0167-8140
VL - 195
JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
M1 - 110273
ER -