TY - JOUR
T1 - Bone marrow contribution to the heart from development to adulthood
AU - Sampaio-Pinto, Vasco
AU - Ruiz-Villalba, Adrián
AU - Nascimento, Diana S.
AU - Pérez-Pomares, José M.
N1 - Funding Information:
We want to thank present and past members of our laboratories for their contribution to this review. This work was supported by the Spanish Ministry of Sciences Plan Estatal I+D+i [ RTI2018-095410-RB-I00 ]; the Instituto de Salud Carlos III [ RD16/0011/0030 ]; and the European Regional Development Fund (ERDF) funds through the University of Málaga I Plan Propio [ UMA18-FEDERJA-146 ] to JMPP; by the European Regional Development Fund (ERDF) funds through COMPETE 2020 , Portugal 2020 and FCT (Fundação para a Ciência e Tecnologia [ POCI-01-0145-FEDER-030985 ] and [ CEECINST/00091/2018 ]) to DSN; and by FCT and Ministério da Ciência, Tecnologia e Inovação in the framework of the individual fellowship SFRH/BD/111799/2015 to VSP.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/4
Y1 - 2021/4
N2 - Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the cardiac interstitium is continuous and extends throughout adult life. The bone marrow, as the major hematopoietic site of adult individuals, is in charge of renewing all circulating cell types, and it therefore plays a pivotal role in the incorporation of blood cells to the heart. Bone marrow-derived cells are instrumental to tissue homeostasis in the steady-state heart, and are major effectors in cardiac disease progression. This review will provide a comprehensive approach to bone marrow-derived blood cell functions in the heart, and discuss aspects related to hot topics in the cardiovascular field like cell-based heart regeneration strategies.
AB - Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the cardiac interstitium is continuous and extends throughout adult life. The bone marrow, as the major hematopoietic site of adult individuals, is in charge of renewing all circulating cell types, and it therefore plays a pivotal role in the incorporation of blood cells to the heart. Bone marrow-derived cells are instrumental to tissue homeostasis in the steady-state heart, and are major effectors in cardiac disease progression. This review will provide a comprehensive approach to bone marrow-derived blood cell functions in the heart, and discuss aspects related to hot topics in the cardiovascular field like cell-based heart regeneration strategies.
KW - Blood lineages
KW - Cardiac disease
KW - Fetal and adult hematopoiesis
KW - Heart tissue homeostasis
KW - Bone Marrow/physiology
KW - Heart/growth & development
KW - Endothelial Cells/physiology
KW - Humans
KW - Cell Lineage/genetics
KW - Heart Diseases/genetics
KW - Bone Marrow Cells/physiology
KW - Regeneration/physiology
KW - Hematopoietic Stem Cells/physiology
KW - Cell Differentiation/genetics
UR - http://www.scopus.com/inward/record.url?scp=85086832628&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2020.06.008
DO - 10.1016/j.semcdb.2020.06.008
M3 - Review article
C2 - 32591270
AN - SCOPUS:85086832628
SN - 1084-9521
VL - 112
SP - 16
EP - 26
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -