TY - JOUR
T1 - BMI is not independently associated with coronary artery calcification in a large single-center CT cohort
AU - Altintas, Sibel
AU - van Workum, Samanta
AU - Kok, Madeleine
AU - Joosen, Ivo A P G
AU - Versteylen, Mathijs O
AU - Nelemans, Patricia J
AU - Wildberger, Joachim E
AU - Crijns, Harry J G M
AU - Das, Marco
AU - Kietselaer, Bas L J H
N1 - Publisher Copyright:
© 2022 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.
PY - 2023/4
Y1 - 2023/4
N2 - OBJECTIVE: Obesity is associated with cardiovascular disease (CVD) and CVD mortality. However, previous reports showed a paradoxical protective effect in patients with known CVD referred as "obesity paradox". Therefore, the aim of the present study was to investigate the association of body mass index (BMI) with coronary artery calcification (CAC) in a large outpatient cardiac CT cohort.METHODS: 4.079 patients who underwent cardiac CT between December 2007-May 2014 were analyzed. BMI and clinical risk factors (current smoking, diabetes mellitus type 2, family history, systolic blood pressure, lipid spectrum) were assessed. Missing values were imputed using multiple imputation. CAC extent was categorized as absent (0), mild (>0-100), moderate (>100-400) and severe (>400).RESULTS: Multivariable multinomial logistic regression analysis, including all risk factors as independent variables, showed no association between BMI and CAC. Using absence of calcification as reference category, the odds ratios per unit increase in BMI were 1.01 for mild; 1.02 for moderate; and 1.00 for severe CAC (p-values ≥0.103).CONCLUSIONS: No statistically significant association was observed between BMI and CAC after adjustment for other risk factors.
AB - OBJECTIVE: Obesity is associated with cardiovascular disease (CVD) and CVD mortality. However, previous reports showed a paradoxical protective effect in patients with known CVD referred as "obesity paradox". Therefore, the aim of the present study was to investigate the association of body mass index (BMI) with coronary artery calcification (CAC) in a large outpatient cardiac CT cohort.METHODS: 4.079 patients who underwent cardiac CT between December 2007-May 2014 were analyzed. BMI and clinical risk factors (current smoking, diabetes mellitus type 2, family history, systolic blood pressure, lipid spectrum) were assessed. Missing values were imputed using multiple imputation. CAC extent was categorized as absent (0), mild (>0-100), moderate (>100-400) and severe (>400).RESULTS: Multivariable multinomial logistic regression analysis, including all risk factors as independent variables, showed no association between BMI and CAC. Using absence of calcification as reference category, the odds ratios per unit increase in BMI were 1.01 for mild; 1.02 for moderate; and 1.00 for severe CAC (p-values ≥0.103).CONCLUSIONS: No statistically significant association was observed between BMI and CAC after adjustment for other risk factors.
KW - cardiovascular disease
KW - computed tomography
KW - coronary artery disease (CAD)
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85137489563&partnerID=8YFLogxK
U2 - 10.1002/osp4.636
DO - 10.1002/osp4.636
M3 - Article
C2 - 37034565
SN - 2055-2238
VL - 9
SP - 172
EP - 178
JO - Obesity science & practice
JF - Obesity science & practice
IS - 2
ER -