Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis

doi:10.3233/JAD-240119

Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis

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Abstract

Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease.

Original language	English
Pages (from-to)	1207-1215
Number of pages	9
Journal	Journal of Alzheimer's disease : JAD
Volume	99
Issue number	4
Early online date	21 May 2024
DOIs	https://doi.org/10.3233/JAD-240119
Publication status	Published - 2024

Keywords

Alzheimer’s disease
amyloid
biomarkers
blood pressure
dementia
orthostatic hypotension
tau proteins

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@article{ef0edcb45b364a2dac9822cf361c0813,

title = "Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis",

abstract = " Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease.",

keywords = "Alzheimer{\textquoteright}s disease, amyloid, biomarkers, blood pressure, dementia, orthostatic hypotension, tau proteins",

author = "Starmans, \{Naomi Louisa Paula\} and Kappelle, \{Laurens Jaap\} and Majon Muller and Julie Staals and Teunissen, \{Charlotte Elisabeth\} and Biessels, \{Geert Jan\} and \{van der Flier\}, \{Wiesje Maria\} and Wolters, \{Frank Johannes\}",

note = "Publisher Copyright: {\textcopyright} 2024 - The authors. Published by IOS Press.",

year = "2024",

doi = "10.3233/JAD-240119",

language = "English",

volume = "99",

pages = "1207--1215",

journal = "Journal of Alzheimer's disease : JAD",

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T1 - Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease

T2 - A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis

AU - Starmans, Naomi Louisa Paula

AU - Kappelle, Laurens Jaap

AU - Muller, Majon

AU - Staals, Julie

AU - Teunissen, Charlotte Elisabeth

AU - Biessels, Geert Jan

AU - van der Flier, Wiesje Maria

AU - Wolters, Frank Johannes

PY - 2024

Y1 - 2024

N2 - Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease.

AB - Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease.

KW - Alzheimer’s disease

KW - amyloid

KW - biomarkers

KW - blood pressure

KW - dementia

KW - orthostatic hypotension

KW - tau proteins

UR - https://www.scopus.com/pages/publications/85196229731

U2 - 10.3233/JAD-240119

DO - 10.3233/JAD-240119

M3 - Article

C2 - 38788076

SN - 1875-8908

VL - 99

SP - 1207

EP - 1215

JO - Journal of Alzheimer's disease : JAD

JF - Journal of Alzheimer's disease : JAD

IS - 4

ER -

Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis

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Keywords

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