TY - JOUR
T1 - Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease
T2 - A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis
AU - Starmans, Naomi Louisa Paula
AU - Kappelle, Laurens Jaap
AU - Muller, Majon
AU - Staals, Julie
AU - Teunissen, Charlotte Elisabeth
AU - Biessels, Geert Jan
AU - van der Flier, Wiesje Maria
AU - Wolters, Frank Johannes
PY - 2024
Y1 - 2024
N2 - Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease.
AB - Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease.
KW - Alzheimer’s disease
KW - amyloid
KW - biomarkers
KW - blood pressure
KW - dementia
KW - orthostatic hypotension
KW - tau proteins
UR - http://www.scopus.com/inward/record.url?scp=85196229731&partnerID=8YFLogxK
U2 - 10.3233/JAD-240119
DO - 10.3233/JAD-240119
M3 - Article
C2 - 38788076
VL - 99
SP - 1207
EP - 1215
JO - Journal of Alzheimer's disease : JAD
JF - Journal of Alzheimer's disease : JAD
IS - 4
ER -