Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important

Gert J. Wenting; Peter J. Blankestijn; Don Poldermans; Jos van Geelen; Frans H.M. Derkx; Arie J.Man in t. Veld; Maarten A.D.H. Schalekamp

doi:10.1016/0002-9149(87)90061-0

Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important

Gert J. Wenting, Peter J. Blankestijn, Don Poldermans, Jos van Geelen, Frans H.M. Derkx, Arie J.Man in t. Veld, Maarten A.D.H. Schalekamp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

36 Citations (Scopus)

Abstract

The kinetics of blood pressure changes and plasma angiotensin converting enzyme (ACE) inhibition in response to ramipril (HOE 498), 10 mg orally, were studied in 6 nephrectomized subjects 12 hours after ultrafiltration and in 10 patients with essential hypertension. Ramipril lowered supine and standing blood pressure in both groups, but the effect was greater in essential hypertension. The maximal blood pressure response followed the effect on plasma ACE after a lag time of 3 to 4 hours in both groups. These data provide indirect evidence that ramipril lowers blood pressure, at least in part, independently of its effect on the circulating renin-angiotensin system, possibly by acting on tissue ACE.

Original language	English
Journal	The American Journal of Cardiology
Volume	59
Issue number	10
DOIs	https://doi.org/10.1016/0002-9149(87)90061-0
Publication status	Published - 24 Apr 1987

Access to Document

10.1016/0002-9149(87)90061-0

Cite this

Wenting, G. J., Blankestijn, P. J., Poldermans, D., van Geelen, J., Derkx, F. H. M., Veld, A. J. M. I. T., & Schalekamp, M. A. D. H. (1987). Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important. The American Journal of Cardiology, 59(10). https://doi.org/10.1016/0002-9149(87)90061-0

@article{528fbe7c836e4675a410872b1ff4165b,

title = "Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important",

abstract = "The kinetics of blood pressure changes and plasma angiotensin converting enzyme (ACE) inhibition in response to ramipril (HOE 498), 10 mg orally, were studied in 6 nephrectomized subjects 12 hours after ultrafiltration and in 10 patients with essential hypertension. Ramipril lowered supine and standing blood pressure in both groups, but the effect was greater in essential hypertension. The maximal blood pressure response followed the effect on plasma ACE after a lag time of 3 to 4 hours in both groups. These data provide indirect evidence that ramipril lowers blood pressure, at least in part, independently of its effect on the circulating renin-angiotensin system, possibly by acting on tissue ACE.",

author = "Wenting, \{Gert J.\} and Blankestijn, \{Peter J.\} and Don Poldermans and \{van Geelen\}, Jos and Derkx, \{Frans H.M.\} and Veld, \{Arie J.Man in t.\} and Schalekamp, \{Maarten A.D.H.\}",

year = "1987",

month = apr,

day = "24",

doi = "10.1016/0002-9149(87)90061-0",

language = "English",

volume = "59",

journal = "The American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier",

number = "10",

}

Wenting, GJ, Blankestijn, PJ, Poldermans, D, van Geelen, J, Derkx, FHM, Veld, AJMIT & Schalekamp, MADH 1987, 'Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important', The American Journal of Cardiology, vol. 59, no. 10. https://doi.org/10.1016/0002-9149(87)90061-0

Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important. / Wenting, Gert J.; Blankestijn, Peter J.; Poldermans, Don et al.
In: The American Journal of Cardiology, Vol. 59, No. 10, 24.04.1987.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril

T2 - Indirect evidence that inhibition of tissue angiotensin converting enzyme is important

AU - Wenting, Gert J.

AU - Blankestijn, Peter J.

AU - Poldermans, Don

AU - van Geelen, Jos

AU - Derkx, Frans H.M.

AU - Veld, Arie J.Man in t.

AU - Schalekamp, Maarten A.D.H.

PY - 1987/4/24

Y1 - 1987/4/24

N2 - The kinetics of blood pressure changes and plasma angiotensin converting enzyme (ACE) inhibition in response to ramipril (HOE 498), 10 mg orally, were studied in 6 nephrectomized subjects 12 hours after ultrafiltration and in 10 patients with essential hypertension. Ramipril lowered supine and standing blood pressure in both groups, but the effect was greater in essential hypertension. The maximal blood pressure response followed the effect on plasma ACE after a lag time of 3 to 4 hours in both groups. These data provide indirect evidence that ramipril lowers blood pressure, at least in part, independently of its effect on the circulating renin-angiotensin system, possibly by acting on tissue ACE.

AB - The kinetics of blood pressure changes and plasma angiotensin converting enzyme (ACE) inhibition in response to ramipril (HOE 498), 10 mg orally, were studied in 6 nephrectomized subjects 12 hours after ultrafiltration and in 10 patients with essential hypertension. Ramipril lowered supine and standing blood pressure in both groups, but the effect was greater in essential hypertension. The maximal blood pressure response followed the effect on plasma ACE after a lag time of 3 to 4 hours in both groups. These data provide indirect evidence that ramipril lowers blood pressure, at least in part, independently of its effect on the circulating renin-angiotensin system, possibly by acting on tissue ACE.

UR - https://www.scopus.com/pages/publications/0023265834

U2 - 10.1016/0002-9149(87)90061-0

DO - 10.1016/0002-9149(87)90061-0

M3 - Article

C2 - 3034041

AN - SCOPUS:0023265834

SN - 0002-9149

VL - 59

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

IS - 10

ER -

Blood pressure response of nephrectomized subjects and patients with essential hypertension to ramipril: Indirect evidence that inhibition of tissue angiotensin converting enzyme is important

Abstract

Access to Document

Other files and links

Fingerprint

Cite this