TY - JOUR
T1 - Blood pressure and risk of myocardial infarction in elderly men and women
T2 - The Rotterdam Study
AU - Van den Hoogen, Peggy C.W.
AU - Van Popele, Nicole M.
AU - Feskens, Edith J.M.
AU - Van der Kuip, Deirdre A.M.
AU - Grobbee, Diederik E.
AU - Hofman, Albert
AU - Witteman, Jacqueline C.M.
PY - 1999/11/11
Y1 - 1999/11/11
N2 - Objective. To study the association between blood pressure and risk of myocardial infarction in elderly subjects. Design. Prospective cohort study. Setting. The Rotterdam Study, a Dutch population-based study. Participants. 6004 men and women aged ≥ 55 years. Main outcome measures. Fatal or non-fatal myocardial infarction (n = 190) during a 4-year follow-up. Results. After excluding participants using blood pressure-lowering medication and participants with a history of myocardial infarction, increasing levels of systolic blood pressure (SBP) were associated with increasing risk of first myocardial infarction (P for trend < 0.0001). The relative risk (RR) for an SBP of 160 mmHg or higher was 5.7 (95% confidence interval (CI) 1.9-17.1) compared with an SBP below 120 mmHg. Increasing diastolic blood pressure (DBP) was also associated with increasing risk of first myocardial infarction, with the RR reaching 2.5 (95% CI 1.4-4.5) in subjects with values of 80-90 mmHg compared with values below 70 mmHg (P for trend < 0.05). Analyses in subjects aged 70 years and over showed that the positive associations between SBP and DBP and risk of first myocardial infarction remained at older age. Conclusion. These findings in a relatively healthy cohort of elderly subjects do not provide evidence for a J- or U-shaped relation between SBP and DBP and risk of first myocardial infarction. They suggest that the risk of first myocardial infarction increases with increasing level of systolic and diastolic blood pressure and that this relationship persists into older age.
AB - Objective. To study the association between blood pressure and risk of myocardial infarction in elderly subjects. Design. Prospective cohort study. Setting. The Rotterdam Study, a Dutch population-based study. Participants. 6004 men and women aged ≥ 55 years. Main outcome measures. Fatal or non-fatal myocardial infarction (n = 190) during a 4-year follow-up. Results. After excluding participants using blood pressure-lowering medication and participants with a history of myocardial infarction, increasing levels of systolic blood pressure (SBP) were associated with increasing risk of first myocardial infarction (P for trend < 0.0001). The relative risk (RR) for an SBP of 160 mmHg or higher was 5.7 (95% confidence interval (CI) 1.9-17.1) compared with an SBP below 120 mmHg. Increasing diastolic blood pressure (DBP) was also associated with increasing risk of first myocardial infarction, with the RR reaching 2.5 (95% CI 1.4-4.5) in subjects with values of 80-90 mmHg compared with values below 70 mmHg (P for trend < 0.05). Analyses in subjects aged 70 years and over showed that the positive associations between SBP and DBP and risk of first myocardial infarction remained at older age. Conclusion. These findings in a relatively healthy cohort of elderly subjects do not provide evidence for a J- or U-shaped relation between SBP and DBP and risk of first myocardial infarction. They suggest that the risk of first myocardial infarction increases with increasing level of systolic and diastolic blood pressure and that this relationship persists into older age.
KW - Blood pressure
KW - Elderly
KW - Myocardial infarction
KW - Prospective study
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=0032708388&partnerID=8YFLogxK
U2 - 10.1097/00004872-199917100-00003
DO - 10.1097/00004872-199917100-00003
M3 - Article
C2 - 10526896
AN - SCOPUS:0032708388
SN - 0263-6352
VL - 17
SP - 1373
EP - 1378
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 10
ER -