Blood oxygenation level-dependent/functional magnetic resonance imaging: Underpinnings, practice, and perspectives

Jeroen C.W. Siero; Alex Bhogal; J. Martijn Jansma

doi:10.1016/j.cpet.2013.04.003

Blood oxygenation level-dependent/functional magnetic resonance imaging: Underpinnings, practice, and perspectives

Jeroen C.W. Siero^*, Alex Bhogal, J. Martijn Jansma

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Imaging studies using blood oxygenation level-dependent (BOLD) functional magnetic resonance (fMR) imaging have provided significant insight into the functional workings of the human brain. BOLD fMR imaging-based techniques have matured to include clinically viable imaging techniques that may one day render invasive diagnostic procedures unnecessary. This article explains how BOLD fMR imaging was developed. The characteristics of the BOLD signal are explained and the concepts of specificity and sensitivity are addressed with respect to pulse sequence and field strength. An overview of recent clinical applications is provided and future directions and perspectives are discussed.

Original language	English
Pages (from-to)	329-344
Number of pages	16
Journal	PET Clinics
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/j.cpet.2013.04.003
Publication status	Published - Jul 2013

Keywords

Blood oxygenation level-dependent contrast
Brain function
Cerebrovascular reactivity
Epilepsy
Functional MR imaging
Neuroimaging
Resting state
Tumor surgery

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10.1016/j.cpet.2013.04.003

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title = "Blood oxygenation level-dependent/functional magnetic resonance imaging: Underpinnings, practice, and perspectives",

abstract = "Imaging studies using blood oxygenation level-dependent (BOLD) functional magnetic resonance (fMR) imaging have provided significant insight into the functional workings of the human brain. BOLD fMR imaging-based techniques have matured to include clinically viable imaging techniques that may one day render invasive diagnostic procedures unnecessary. This article explains how BOLD fMR imaging was developed. The characteristics of the BOLD signal are explained and the concepts of specificity and sensitivity are addressed with respect to pulse sequence and field strength. An overview of recent clinical applications is provided and future directions and perspectives are discussed.",

keywords = "Blood oxygenation level-dependent contrast, Brain function, Cerebrovascular reactivity, Epilepsy, Functional MR imaging, Neuroimaging, Resting state, Tumor surgery",

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year = "2013",

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language = "English",

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T2 - Underpinnings, practice, and perspectives

AU - Siero, Jeroen C.W.

AU - Bhogal, Alex

AU - Jansma, J. Martijn

PY - 2013/7

Y1 - 2013/7

N2 - Imaging studies using blood oxygenation level-dependent (BOLD) functional magnetic resonance (fMR) imaging have provided significant insight into the functional workings of the human brain. BOLD fMR imaging-based techniques have matured to include clinically viable imaging techniques that may one day render invasive diagnostic procedures unnecessary. This article explains how BOLD fMR imaging was developed. The characteristics of the BOLD signal are explained and the concepts of specificity and sensitivity are addressed with respect to pulse sequence and field strength. An overview of recent clinical applications is provided and future directions and perspectives are discussed.

AB - Imaging studies using blood oxygenation level-dependent (BOLD) functional magnetic resonance (fMR) imaging have provided significant insight into the functional workings of the human brain. BOLD fMR imaging-based techniques have matured to include clinically viable imaging techniques that may one day render invasive diagnostic procedures unnecessary. This article explains how BOLD fMR imaging was developed. The characteristics of the BOLD signal are explained and the concepts of specificity and sensitivity are addressed with respect to pulse sequence and field strength. An overview of recent clinical applications is provided and future directions and perspectives are discussed.

KW - Blood oxygenation level-dependent contrast

KW - Brain function

KW - Cerebrovascular reactivity

KW - Epilepsy

KW - Functional MR imaging

KW - Neuroimaging

KW - Resting state

KW - Tumor surgery

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DO - 10.1016/j.cpet.2013.04.003

M3 - Review article

AN - SCOPUS:84879604994

SN - 1556-8598

VL - 8

SP - 329

EP - 344

JO - PET Clinics

JF - PET Clinics

IS - 3

ER -

Blood oxygenation level-dependent/functional magnetic resonance imaging: Underpinnings, practice, and perspectives

Abstract

Keywords

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