Birth asphyxia-induced brain damage: The long road to optimal reduction and prevention!

Frank Van Bel; Floris Groenendaal

doi:10.21037/pm.2019.11.02

Birth asphyxia-induced brain damage: The long road to optimal reduction and prevention!

Frank Van Bel^*, Floris Groenendaal

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Moderate hypothermia (HT) is the only established therapy to reduce birth asphyxia-induced brain injury in (near) term neonates, but it is conceivable that pharmacological add-on therapy during or after HT can further reduce brain damage. This paper summarizes neuroprotective interventions with drugs that have possible potential to do so. We finally discuss the potential role of autologous and allogenic mesenchymal stem cell therapy for the repair of birth asphyxia-related brain injury.

Original language	English
Article number	3
Number of pages	13
Journal	Pediatric Medicine
Volume	3
DOIs	https://doi.org/10.21037/pm.2019.11.02
Publication status	Published - May 2020

Keywords

(near) term neonate
Birth asphyxia
Pharmacological neuroprotection

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abstract = "Moderate hypothermia (HT) is the only established therapy to reduce birth asphyxia-induced brain injury in (near) term neonates, but it is conceivable that pharmacological add-on therapy during or after HT can further reduce brain damage. This paper summarizes neuroprotective interventions with drugs that have possible potential to do so. We finally discuss the potential role of autologous and allogenic mesenchymal stem cell therapy for the repair of birth asphyxia-related brain injury. ",

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AB - Moderate hypothermia (HT) is the only established therapy to reduce birth asphyxia-induced brain injury in (near) term neonates, but it is conceivable that pharmacological add-on therapy during or after HT can further reduce brain damage. This paper summarizes neuroprotective interventions with drugs that have possible potential to do so. We finally discuss the potential role of autologous and allogenic mesenchymal stem cell therapy for the repair of birth asphyxia-related brain injury.

KW - (near) term neonate

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KW - Pharmacological neuroprotection

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DO - 10.21037/pm.2019.11.02

M3 - Review article

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ER -

Birth asphyxia-induced brain damage: The long road to optimal reduction and prevention!

Abstract

Keywords

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