TY - JOUR
T1 - Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder
T2 - A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project
AU - Sajatovic, Martha
AU - Rej, Soham
AU - Almeida, Osvaldo P
AU - Altinbas, Kursat
AU - Balanzá-Martínez, Vicent
AU - Barbosa, Izabela G
AU - Beunders, Alexandra J M
AU - Blumberg, Hilary P
AU - Briggs, Farren B S
AU - Dols, Annemiek
AU - Forester, Brent P
AU - Forlenza, Orestes V
AU - Gildengers, Ariel G
AU - Jimenez, Esther
AU - Klaus, Federica
AU - Lafer, Beny
AU - Mulsant, Benoit
AU - Mwangi, Benson
AU - Nunes, Paula Villela
AU - Olagunju, Andrew T
AU - Oluwaniyi, Stephen
AU - Orhan, Melis
AU - Patrick, Regan E
AU - Radua, Joaquim
AU - Rajji, Tarek
AU - Sarna, Kaylee
AU - Schouws, Sigfried
AU - Simhandl, Christian
AU - Sekhon, Harmehr
AU - Soares, Jair C
AU - Sutherland, Ashley N
AU - Teixeira, Antonio L
AU - Tsai, Shangying
AU - Vidal-Rubio, Sonia
AU - Vieta, Eduard
AU - Yala, Joy
AU - Eyler, Lisa T
N1 - Publisher Copyright:
© 2024 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
PY - 2024/3
Y1 - 2024/3
N2 - Objectives: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. Design/Methods: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601). Results: Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning. Conclusions: In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.
AB - Objectives: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. Design/Methods: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601). Results: Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning. Conclusions: In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.
KW - aging
KW - bipolar disorder
KW - depression
KW - functioning
KW - mania
KW - medical burden
UR - http://www.scopus.com/inward/record.url?scp=85188519994&partnerID=8YFLogxK
U2 - 10.1002/gps.6057
DO - 10.1002/gps.6057
M3 - Article
C2 - 38511929
SN - 0885-6230
VL - 39
SP - 1
EP - 10
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
IS - 3
M1 - e6057
ER -