TY - JOUR
T1 - Bipolar Disorder Among Older Adults
T2 - Newer Evidence to Guide Clinical Practice
AU - Dols, Annemiek
AU - Sekhon, Harmehr
AU - Rej, Soham
AU - Klaus, Federica
AU - Bodenstein, Katie
AU - Sajatovic, Martha
N1 - Copyright © 2023 by the American Psychiatric Association.
PY - 2023/10
Y1 - 2023/10
N2 - The term
older-age bipolar disorder (OABD) refers to patients with bipolar disorder who are ages 50 and older. Research findings suggest important differences, including the attenuation of manic symptoms with age and the occurrence of multiple somatic comorbid conditions. Although the pharmacological treatment of OABD is fairly similar, adverse effects, somatic comorbidity, and drug-drug interactions are more common. Lithium is effective in treating OABD and may have the potential to be neuroprotective. Anticonvulsants and second-generation antipsychotics have a growing evidence supporting their use in treating OABD. Behavioral intervention can be a helpful adjunct to pharmacological treatment. Clinicians and health care systems need to be prepared to provide care and services to individuals with bipolar disorder throughout the life span. Although older adults have typically been excluded from bipolar disorder RCTs, emerging efforts organized by global advocates and harnessing teams of clinicians and scientists have the potential to advance care.
AB - The term
older-age bipolar disorder (OABD) refers to patients with bipolar disorder who are ages 50 and older. Research findings suggest important differences, including the attenuation of manic symptoms with age and the occurrence of multiple somatic comorbid conditions. Although the pharmacological treatment of OABD is fairly similar, adverse effects, somatic comorbidity, and drug-drug interactions are more common. Lithium is effective in treating OABD and may have the potential to be neuroprotective. Anticonvulsants and second-generation antipsychotics have a growing evidence supporting their use in treating OABD. Behavioral intervention can be a helpful adjunct to pharmacological treatment. Clinicians and health care systems need to be prepared to provide care and services to individuals with bipolar disorder throughout the life span. Although older adults have typically been excluded from bipolar disorder RCTs, emerging efforts organized by global advocates and harnessing teams of clinicians and scientists have the potential to advance care.
U2 - 10.1176/appi.focus.20230010
DO - 10.1176/appi.focus.20230010
M3 - Article
C2 - 38695001
SN - 1541-4094
VL - 21
SP - 370
EP - 379
JO - Focus (American Psychiatric Publishing)
JF - Focus (American Psychiatric Publishing)
IS - 4
ER -