TY - JOUR
T1 - Biomarkers of endothelial dysfunction and cognition
T2 - A two-step IPD meta-analysis
AU - Beran, Magdalena
AU - Jansen, Willemijn J.
AU - Oomens, Julie E.
AU - Moonen, Justine E.F.
AU - Slagboom, P. Eline
AU - Huisman, Martijn
AU - Kok, Almar A.L.
AU - Nooyens, Astrid C.J.
AU - Verschuren, Wilhelmina Maria Monique
AU - Stehouwer, Coen D.A.
AU - Schalkwijk, Casper
AU - Köhler, Sebastian
AU - Beekman, Marian
AU - Slagboom, Pieternella Eline
AU - Wolters, Frank J.
AU - Ikram, M. Arfan
AU - Vallerga, Costanza L.
AU - van Meurs, Joyce B.J.
AU - Ghanbari, Mohsen
AU - Vonk, Jet M.J.
AU - Geerlings, Mirjam I.
AU - van Sloten, Thomas T.
AU - Schram, Miranda T.
N1 - Publisher Copyright:
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/12
Y1 - 2024/12
N2 - INTRODUCTION: This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline. METHODS: Data from 9414 individuals from eight Dutch cohorts were included (Ø age-range: 57–93 years). Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses. RESULTS: A higher endothelial dysfunction composite score was cross-sectionally associated with worse performance on executive function, processing speed, delayed memory, and attention, but not immediate memory or language (pooled β-range: −0.04, −0.02). We found no association with change in cognition over time. DISCUSSION: This comprehensive two-step, individual participant data (IPD) meta-analysis showed a small, consistent cross-sectional association between endothelial dysfunction and worse cognitive performance across multiple domains but no support for a longitudinal association. Highlights: Prior evidence on endothelial dysfunction (ED) biomarkers and cognition is conflicting. This two-step, individual participant data (IPD) meta-analysis used data from eight Dutch cohorts. ED was consistently associated with concurrent cognition. ED was not associated with a change in cognition over time. The association of ED with current cognition may be generic.
AB - INTRODUCTION: This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline. METHODS: Data from 9414 individuals from eight Dutch cohorts were included (Ø age-range: 57–93 years). Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses. RESULTS: A higher endothelial dysfunction composite score was cross-sectionally associated with worse performance on executive function, processing speed, delayed memory, and attention, but not immediate memory or language (pooled β-range: −0.04, −0.02). We found no association with change in cognition over time. DISCUSSION: This comprehensive two-step, individual participant data (IPD) meta-analysis showed a small, consistent cross-sectional association between endothelial dysfunction and worse cognitive performance across multiple domains but no support for a longitudinal association. Highlights: Prior evidence on endothelial dysfunction (ED) biomarkers and cognition is conflicting. This two-step, individual participant data (IPD) meta-analysis used data from eight Dutch cohorts. ED was consistently associated with concurrent cognition. ED was not associated with a change in cognition over time. The association of ED with current cognition may be generic.
KW - biomarkers
KW - cognition
KW - cohort
KW - endothelial dysfunction
KW - meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85206908694&partnerID=8YFLogxK
U2 - 10.1002/alz.14272
DO - 10.1002/alz.14272
M3 - Article
C2 - 39428719
AN - SCOPUS:85206908694
SN - 1552-5260
VL - 20
SP - 8402
EP - 8411
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 12
M1 - doi.org/10.1002/alz.14272
ER -