@article{00463dad1e694a6d86409c55ad1460af,
title = "Biomarker bei der allergen-immuntherapie - Ein EAaci positionspapier",
abstract = "Background: Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex interaction between patient, allergy triggers, symptomatology and vaccines used for AIT, some patients do not respond optimally to the treatment. Furthermore, there are no validated or generally accepted candidate biomarkers that are predictive of the clinical response to AIT. Clinical management of patients receiving AIT and efficacy in randomized controlled trials for drug development could be enhanced by predictive biomarkers. Method: The EAACI taskforce reviewed all candidate biomarkers used in clinical trials of AR patients with and without asthma in a literature review. Biomarkers were grouped into seven domains: (i) IgE (total IgE, specific IgE, and sIgE/Total IgE ratio), (ii) IgG-subclasses (sIgG1, sIgG4 including SIgE/ IgG4 ratio), (iii) Serum inhibitory activity for IgE (IgE-FAB and IgE-BF), (iv) Basophil activation, (v) Cytokines and Chemokines, (vi) Cellular markers (T regulatory cells, B regulatory cells, and dendritic cells) and (vii) In vivo biomarkers (including provocation tests). Results: All biomarkers were reviewed in the light of their potential advantages as well as their respective drawbacks. Unmet needs and specific recommendations on all seven domains were addressed. Conclusions: It is recommended to explore the use of allergen-specific IgG4 as a biomarker for compliance. sIgE/tIgE and IgE-FAB are considered as potential surrogate candidate biomarkers. Cytokine/chemokines and cellular reponses provided insight into the mechanisms of AIT. More studies for confirmation and interpretation of the possible association with the clinical response to AIT are needed.",
keywords = "Allergen immunotherapy, Basophil activation, Biomarkers, IgE-FAB, IgG4",
author = "Jakwerth, {C. A.} and Shamji, {M. H.} and Kappen, {J. H.} and M. Akdis and E. Jensen-Jarolim and Knol, {E. F.} and J. Kleine-Tebbe and B. Bohle and Chaker, {A. M.} and Till, {S. J.} and R. Valenta and Poulsen, {L. K.} and Calderon, {M. A.} and P. Demoly and O. Pfaar and L. Jacobsen and Durham, {S. R.} and Schmidt-Weber, {C. B.}",
note = "Funding Information: 1Zentrum f{\"u}r Allergie und Umwelt (ZAUM), Technische Universit{\"a}t und Helmholtz Zentrum M{\"u}nchen, Member of the Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), 2Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, 3MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, 4Allergy and Clinical Immunology, Immunomodulation and Tolerance Group, Imperial College London, UK, 5Department of Pulmonology, STZ Centre of Excellence for Asthma & COPD, Sint Franciscus Vlietland Group, Rotterdam, The Netherlands, 6Institut f{\"u}r Pathophysiologie und Allergieforschung, Zentrum f{\"u}r Pathophysiologie, Infektiologie und Immunologie, Medizinische Universit{\"a}t Wien, 7Interuniversit{\"a}res Messerli-Forschungsinstitut, Veterin{\"a}rmedizinische Universit{\"a}t Wien, Medizinische Universit{\"a}t Wien und Universit{\"a}t Wien, {\"O}sterreich, 8Departments Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands, 9Allergie-und Asthma-Zentrum Westend, Praxis Hanf, Ackermann u. Kleine-Tebbe, Berlin, 10Institut f{\"u}r Pathophysiologie und Allergieforschung, Medizinische Universit{\"a}t Wien, {\"O}sterreich, 11Hals-Nasen-Ohren-Klinik, Bereich Allergologie, Klinikum rechts der Isar, Technische Universit{\"a}t, M{\"u}nchen, 12Division of Asthma, Allergy and Lung Biology, King{\textquoteright}s College London, 13Department of Allergy, Guy{\textquoteright}s and St. Thomas{\textquoteright} NHS Foundation Trust, London, UK, 14Abteilung f{\"u}r Immunpathologie, Institut f{\"u}r Pathophysiologie und Allergieforschung, Zentrum f{\"u}r Pathophysiologie, Infektiologie und Immunologie, Medizinische Universit{\"a}t Wien, {\"O}sterreich, 15Allergy Clinic, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, 16Division of Allergy, Department of Pulmonology, Arnaud de Villeneuve Hospital, University Hospital of Montpellier and Sorbonne University, Paris, France, 17Universit{\"a}tsklinik f{\"u}r Hals-Nasen-Ohren-Heilkunde, Medizinische Fakult{\"a}t Mannheim, Universit{\"a}t Heidelberg, Mannheim, 18 Zentrum f{\"u}r Rhinologie und Allergologie Wiesbaden, 19Allergy Learning and Consulting, Copenhagen, Denmark, 20Schweizerisches Institut f{\"u}r Allergie-und Asthmaforschung (SIAF), Universit{\"a}t Z{\"u}rich, Davos, Schweiz Publisher Copyright: {\textcopyright} 2018 Dustri-Verlag Dr. Karl Feistle",
year = "2018",
month = sep,
day = "1",
doi = "10.5414/ALX01992",
language = "German",
volume = "41",
pages = "376--385",
journal = "Allergologie",
issn = "0344-5062",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "9",
}