TY - JOUR
T1 - Biochemical Recurrence in Prostate Cancer
T2 - The European Association of Urology Prostate Cancer Guidelines Panel Recommendations
AU - Van den Broeck, Thomas
AU - van den Bergh, Roderick C N
AU - Briers, Erik
AU - Cornford, Philip
AU - Cumberbatch, Marcus
AU - Tilki, Derya
AU - De Santis, Maria
AU - Fanti, Stefano
AU - Fossati, Nicola
AU - Gillessen, Silke
AU - Grummet, Jeremy P
AU - Henry, Ann M
AU - Lardas, Michael
AU - Liew, Matthew
AU - Mason, Malcolm
AU - Moris, Lisa
AU - Schoots, Ivo G
AU - van der Kwast, Theodorus
AU - van der Poel, Henk
AU - Wiegel, Thomas
AU - Willemse, Peter-Paul M
AU - Rouvière, Olivier
AU - Lam, Thomas B
AU - Mottet, Nicolas
N1 - Funding Information:
Financial disclosures: Thomas Van den Broeck certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: Henk van Der Poel is a company consultant for Intuitive Surgical, has participated in trials for Astellas and Steba Biotech, and has received grant and research support from Astellas. Philip Cornford is a company consultant for Astellas, Ipsen, and Ferring; receives company speaker honoraria from Astellas, Janssen, Ipsen, and Pfizer; participates in trials from Ferring; and receives fellowships and travel grants from Astellas and Janssen. Thomas B. Lam is a company consultant for and has received company speaker honoraria from Pfizer, GSK, Astellas, and Ipsen. Ann M. Henry is a company consultant for Nucletron-Elektra; participates in trials by Cancer Research UK and the National Institute of Health Research (UK); has received travel grants from the Medical Research Council, the National Institute of Health Research (UK), and Cancer Research UK; and has received research grants from Cancer Research UK and the Sir John Fisher Foundation. Malcolm Mason is a company consultant for Ellipses Pharma and Oncotherics. Thomas Wiegel is a member of the advisory board for IPSEN, receives company speaker honoraria from IPSEN and Hexal, is a member of the Janssen Steering Committee, and has participated in the ATLAS/AUO trial. Silke Gillessen is a company consultant for AAA International, Astellas Pharma, Bayer, Bristol-Myers Squibb, Clovis, CureVac, Ferring, Innocrin Pharmaceuticals, Janssen Cilag, MaxIVAX SA, Orion, Roche, Sanofi Aventis Group, Nectar, and ProteoMediX; has received speaker honoraria from Janssen and Novartis; and participates in multiple trials for different companies. Olivier Rouvière has received company speaker honoraria from EDAP-TMS, participates in trials by ESAO-TMS and Vermon, and has received research and travel grants from Philips. Maria De Santis is a company consultant for Amgen, Astellas, AstraZeneca, Bayer, Bristol-Myers Squibb, Celgene, Dendreon, Eisai, ESSA, Ferring, GSK, Incyte, IPSEN, Janssen Cilag, Merck, MSD, Novartis, Pfizer, Pierre Fabre Oncologie, Roche, Sanofi Aventis, SeaGen, Shionogi, Synthon, Takeda, Teva, OncoGenex, and Sandoz; receives speaker honoraria from Amgen, Astellas, AstraZeneca, Bayer, Bristol-Myers Squibb, Ferring, GSK, IPSEN, Janssen Cilag, Merck, MSD, Novartis, Pfizer, Pierre Fabre Oncologie, Roche, Sanofi Aventis, Synthon, and Takeda; participates in trials by the Technical University Munich, Amgen, Astellas, AstraZeneca, Bayer, Bristol-Myers Squibb, Celgene, Dendreon, Eisai, Ferring, GSK, IPSEN, Incyte, Janssen Cilag, Merck, MSD, Novartis, Pfizer, Pierre Fabre Oncologie, Roche, Sanofi Aventis, and SOTIO; participates in various trials as a member of the EORTC GU group; and has received research grants from Pierre Fabre Oncologie and travel grants from Amgen, Astellas, AstraZeneca, Bayer, Bristol-Myers Squibb, Celgene, Dendreon, Ferring, GSK, IPSEN, Incyte, Janssen Cilag, Merck, MSD, Novartis, Pfizer, Pierre Fabre Oncologie, Roche, Sanofi Aventis, SeaGen, Shionogi, Synthon, Takeda, and Teva/OncoGenex. Derya Tilki is a company consultant for Steba Biotech and MDx Health; has received speaker honoraria from Mundipharma, Astellas, and Ribose-pharm; participates in trials by MDxHealth; has received travel and research grants from Janssen; and is a member of the PIONEER consortium. Stefano Fanti is a company consultant for Bayer and ANMI; has received speaker honoraria from Bayer, Genzyme, ANMI, and GE Healthcare; and participates in trials by Amgen, Bayer, BMS, Genzyme, Janssen, Merck, and Novartis. Nicolas Mottet is a company consultant for Janssen, GE, BMS, Sanofi, and Astellas; has received speaker honoraria from Astellas, Pierre Fabre, Steba, Janssen, and Ferring; and has received fellowships and travel grants from Astellas, IPSEN, Sanofi, Janssen, and Roche. Thomas Van den Broeck, Roderick C.N. van den Bergh, Lisa Moris, Erik Briers, Marcus Cumberbatch, Nicola Fossati, Jeremy P. Grummet, Michael Lardas, Matthew Liew, Ivo G. Schoots, Peter-Paul M. Willemse, and Theodorus Van Der Kwast have nothing to disclose.
Publisher Copyright:
© 2019 European Association of Urology
PY - 2020/3/15
Y1 - 2020/3/15
N2 - Biochemical recurrence (BCR) after primary treatment of localized prostate cancer does not necessarily lead to clinically apparent progressive disease. To aid in prognostication, the European Association of Urology prostate cancer guidelines panel undertook a systematic review and successfully developed a novel BCR risk stratification system (groups with a low risk or high risk of BCR) based on disease and prostate-specific antigen characteristics. Patient summary: Following treatment to cure prostate cancer, some patients can develop recurrence of disease identified via a prostate-specific antigen blood test (ie, biochemical recurrence, or BCR). However, not every man who experiences BCR develops progressive disease (symptoms or evidence of disease progression on imaging). We conducted a review of the literature and developed a classification system for predicting which patients might progress to optimize treatment decisions. The EAU-EANM-ESTRO-ESUR-SIOG prostate cancer guidelines panel recommends stratifying patients experiencing biochemical recurrence (BCR) after primary treatment for localized prostate cancer into EAU low-risk and high-risk BCR groups. Each patient's risk profile and life expectancy should be considered when discussing the benefits and toxicities of salvage treatments.
AB - Biochemical recurrence (BCR) after primary treatment of localized prostate cancer does not necessarily lead to clinically apparent progressive disease. To aid in prognostication, the European Association of Urology prostate cancer guidelines panel undertook a systematic review and successfully developed a novel BCR risk stratification system (groups with a low risk or high risk of BCR) based on disease and prostate-specific antigen characteristics. Patient summary: Following treatment to cure prostate cancer, some patients can develop recurrence of disease identified via a prostate-specific antigen blood test (ie, biochemical recurrence, or BCR). However, not every man who experiences BCR develops progressive disease (symptoms or evidence of disease progression on imaging). We conducted a review of the literature and developed a classification system for predicting which patients might progress to optimize treatment decisions. The EAU-EANM-ESTRO-ESUR-SIOG prostate cancer guidelines panel recommends stratifying patients experiencing biochemical recurrence (BCR) after primary treatment for localized prostate cancer into EAU low-risk and high-risk BCR groups. Each patient's risk profile and life expectancy should be considered when discussing the benefits and toxicities of salvage treatments.
KW - Biochemical recurrence
KW - European Association of Urology
KW - Gleason score
KW - Guidelines
KW - Prognostic factors
KW - Prostate cancer
KW - PSA kinetics
KW - Radical prostatectomy
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85067674484&partnerID=8YFLogxK
U2 - 10.1016/j.euf.2019.06.004
DO - 10.1016/j.euf.2019.06.004
M3 - Article
C2 - 31248850
VL - 6
SP - 231
EP - 234
JO - European Urology Focus
JF - European Urology Focus
IS - 2
ER -