Bing–Neel Syndrome: Update on Diagnosis and Treatment

Evangeline Y. Wong; Shirley D’Sa; Monique C. Minnema; Jorge J. Castillo; Dipti Talaulikar

doi:10.3390/hemato3040051

Bing–Neel Syndrome: Update on Diagnosis and Treatment

Evangeline Y. Wong, Shirley D’Sa, Monique C. Minnema, Jorge J. Castillo, Dipti Talaulikar^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Bing–Neel syndrome (BNS) is a rare neurological complication of Waldenström macroglobulinaemia. We highlight key issues in clinical presentation, diagnosis, and treatment while focusing on new and emerging therapies available for patients diagnosed with BNS. It is anticipated that further development of Bruton Tyrosine Kinase (BTK) inhibitors and less toxic chemoimmunotherapies will improve treatment delivery and response.

Original language	English
Pages (from-to)	758-770
Number of pages	13
Journal	Hemato
Volume	3
Issue number	4
DOIs	https://doi.org/10.3390/hemato3040051
Publication status	Published - Dec 2022

Keywords

Bing–Neel syndrome
BTK inhibitors
central nervous system involvement
ibrutinib
lymphoplasmacytic lymphoma
orbital involvement
Waldenström macroglobulinaemia

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title = "Bing–Neel Syndrome: Update on Diagnosis and Treatment",

abstract = "Bing–Neel syndrome (BNS) is a rare neurological complication of Waldenstr{\"o}m macroglobulinaemia. We highlight key issues in clinical presentation, diagnosis, and treatment while focusing on new and emerging therapies available for patients diagnosed with BNS. It is anticipated that further development of Bruton Tyrosine Kinase (BTK) inhibitors and less toxic chemoimmunotherapies will improve treatment delivery and response.",

keywords = "Bing–Neel syndrome, BTK inhibitors, central nervous system involvement, ibrutinib, lymphoplasmacytic lymphoma, orbital involvement, Waldenstr{\"o}m macroglobulinaemia",

author = "Wong, {Evangeline Y.} and Shirley D{\textquoteright}Sa and Minnema, {Monique C.} and Castillo, {Jorge J.} and Dipti Talaulikar",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = dec,

doi = "10.3390/hemato3040051",

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volume = "3",

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T2 - Update on Diagnosis and Treatment

AU - Wong, Evangeline Y.

AU - D’Sa, Shirley

AU - Minnema, Monique C.

AU - Castillo, Jorge J.

AU - Talaulikar, Dipti

PY - 2022/12

Y1 - 2022/12

N2 - Bing–Neel syndrome (BNS) is a rare neurological complication of Waldenström macroglobulinaemia. We highlight key issues in clinical presentation, diagnosis, and treatment while focusing on new and emerging therapies available for patients diagnosed with BNS. It is anticipated that further development of Bruton Tyrosine Kinase (BTK) inhibitors and less toxic chemoimmunotherapies will improve treatment delivery and response.

AB - Bing–Neel syndrome (BNS) is a rare neurological complication of Waldenström macroglobulinaemia. We highlight key issues in clinical presentation, diagnosis, and treatment while focusing on new and emerging therapies available for patients diagnosed with BNS. It is anticipated that further development of Bruton Tyrosine Kinase (BTK) inhibitors and less toxic chemoimmunotherapies will improve treatment delivery and response.

KW - Bing–Neel syndrome

KW - BTK inhibitors

KW - central nervous system involvement

KW - ibrutinib

KW - lymphoplasmacytic lymphoma

KW - orbital involvement

KW - Waldenström macroglobulinaemia

UR - http://www.scopus.com/inward/record.url?scp=85177770354&partnerID=8YFLogxK

U2 - 10.3390/hemato3040051

DO - 10.3390/hemato3040051

M3 - Review article

AN - SCOPUS:85177770354

SN - 2673-6357

VL - 3

SP - 758

EP - 770

JO - Hemato

JF - Hemato

IS - 4

ER -

Bing–Neel Syndrome: Update on Diagnosis and Treatment

Abstract

Keywords

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