TY - CHAP
T1 - Beyond Serotonin
T2 - A Multiaminergic Perspective on Abnormal Behavior
AU - Van Praag, Herman M.
AU - Brown, Serena Lynn
AU - Asnis, Gregory M.
AU - Kahn, Rene S.
AU - Korn, Martin L.
AU - Harkavy-Friedman, Jill M.
AU - Wetzler, Scott
N1 - Publisher Copyright:
© 1991 by Albert Einstein College of Medicine of Yeshiva University.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - This chapter argues that diminished DA metabolism in the nigro-striatal system underlies decreased motor activity and lowered level of initiative, irrespective of nosological diagnosis. L-dopa, in combination with a peripheral decarboxylase inhibitor, was first studied in a group of biochemically undifferentiated, melancholically depressed patients and found to be lacking in overall therapeutic effects. The sequence leading to goal-directed behavior can be disturbed at any junction. The human data suggest that DA is involved in the mobilization, facilitation, and sustenance of goal-directed behavior. The large pool of animal data available is in accord with this conclusion. If 5-HTP’s therapeutic superiority to tryptophan is related to its combined effects on the 5-HT and CA systems, one would expect tryptophan’s antidepressant efficacy to be raised above the significance level by combining it with a compound capable of increasing CA availability. Anxiety is a psychopathological dimension occurring in depression, but by no means specific for that disorder, that also seems to be 5-HT related.
AB - This chapter argues that diminished DA metabolism in the nigro-striatal system underlies decreased motor activity and lowered level of initiative, irrespective of nosological diagnosis. L-dopa, in combination with a peripheral decarboxylase inhibitor, was first studied in a group of biochemically undifferentiated, melancholically depressed patients and found to be lacking in overall therapeutic effects. The sequence leading to goal-directed behavior can be disturbed at any junction. The human data suggest that DA is involved in the mobilization, facilitation, and sustenance of goal-directed behavior. The large pool of animal data available is in accord with this conclusion. If 5-HTP’s therapeutic superiority to tryptophan is related to its combined effects on the 5-HT and CA systems, one would expect tryptophan’s antidepressant efficacy to be raised above the significance level by combining it with a compound capable of increasing CA availability. Anxiety is a psychopathological dimension occurring in depression, but by no means specific for that disorder, that also seems to be 5-HT related.
UR - http://www.scopus.com/inward/record.url?scp=85160495840&partnerID=8YFLogxK
U2 - 10.4324/9781315825861-13
DO - 10.4324/9781315825861-13
M3 - Chapter
AN - SCOPUS:85160495840
SN - 9780876305898
SP - 302
EP - 332
BT - The Role of Serotonin in Psychiatric Disorders
PB - Taylor and Francis Ltd.
ER -