Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases

Shing Fung Lee; Henry C Y Wong; Eva Oldenburger; Srinivas Raman; Gustavo N Marta; Adrian W Chan; Dirk Rades; Yvette M van der Linden; Joanne M van der Velden; Quynh-Nhu Nguyen; J Isabelle Choi; Caroline Hircock; Chiara Doccioli; Claudia Cosma; Saverio Caini; Agata Rembielak; Vassilios Vassiliou; Pierluigi Bonomo; Sara R Alcorn; Candice Johnstone; Charles B Simone; Michael Chao; Tetsuo Saito; Peter J Hoskin; Edward Chow; Samuel Ryu

doi:10.1016/j.ejca.2026.116946

Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases

Shing Fung Lee^*
, Henry C Y Wong
, Eva Oldenburger
, Srinivas Raman
, Gustavo N Marta
, Adrian W Chan
, Dirk Rades
, Yvette M van der Linden
, Joanne M van der Velden
, Quynh-Nhu Nguyen
, J Isabelle Choi
, Caroline Hircock
, Chiara Doccioli
, Claudia Cosma
, Saverio Caini
, Agata Rembielak
, Vassilios Vassiliou
, Pierluigi Bonomo
, Sara R Alcorn
, Candice Johnstone

Charles B Simone, Michael Chao, Tetsuo Saito, Peter J Hoskin, Edward Chow, Samuel Ryu

^*Corresponding author for this work

Department of Radiotherapy

Research output: Contribution to journal › Editorial › Academic › peer-review

Original language	English
Article number	116946
Journal	European Journal of Cancer
Volume	245
Early online date	18 Jul 2026
DOIs	https://doi.org/10.1016/j.ejca.2026.116946
Publication status	E-pub ahead of print - 18 Jul 2026

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10.1016/j.ejca.2026.116946

Cite this

Lee, S. F., Wong, H. C. Y., Oldenburger, E., Raman, S., Marta, G. N., Chan, A. W., Rades, D., van der Linden, Y. M., van der Velden, J. M., Nguyen, Q.-N., Isabelle Choi, J., Hircock, C., Doccioli, C., Cosma, C., Caini, S., Rembielak, A., Vassiliou, V., Bonomo, P., Alcorn, S. R., ... Ryu, S. (2026). Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases. European Journal of Cancer, 245, Article 116946. Advance online publication. https://doi.org/10.1016/j.ejca.2026.116946

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title = "Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases",

author = "Lee, \{Shing Fung\} and Wong, \{Henry C Y\} and Eva Oldenburger and Srinivas Raman and Marta, \{Gustavo N\} and Chan, \{Adrian W\} and Dirk Rades and \{van der Linden\}, \{Yvette M\} and \{van der Velden\}, \{Joanne M\} and Quynh-Nhu Nguyen and \{Isabelle Choi\}, J and Caroline Hircock and Chiara Doccioli and Claudia Cosma and Saverio Caini and Agata Rembielak and Vassilios Vassiliou and Pierluigi Bonomo and Alcorn, \{Sara R\} and Candice Johnstone and Simone, \{Charles B\} and Michael Chao and Tetsuo Saito and Hoskin, \{Peter J\} and Edward Chow and Samuel Ryu",

year = "2026",

month = jul,

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doi = "10.1016/j.ejca.2026.116946",

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Lee, SF, Wong, HCY, Oldenburger, E, Raman, S, Marta, GN, Chan, AW, Rades, D, van der Linden, YM, van der Velden, JM, Nguyen, Q-N, Isabelle Choi, J, Hircock, C, Doccioli, C, Cosma, C, Caini, S, Rembielak, A, Vassiliou, V, Bonomo, P, Alcorn, SR, Johnstone, C, Simone, CB, Chao, M, Saito, T, Hoskin, PJ, Chow, E & Ryu, S 2026, 'Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases', European Journal of Cancer, vol. 245, 116946. https://doi.org/10.1016/j.ejca.2026.116946

TY - JOUR

T1 - Beyond pain response

T2 - rethinking endpoints in radiotherapy trials for bone metastases

AU - Lee, Shing Fung

AU - Wong, Henry C Y

AU - Oldenburger, Eva

AU - Raman, Srinivas

AU - Marta, Gustavo N

AU - Chan, Adrian W

AU - Rades, Dirk

AU - van der Linden, Yvette M

AU - van der Velden, Joanne M

AU - Nguyen, Quynh-Nhu

AU - Isabelle Choi, J

AU - Hircock, Caroline

AU - Doccioli, Chiara

AU - Cosma, Claudia

AU - Caini, Saverio

AU - Rembielak, Agata

AU - Vassiliou, Vassilios

AU - Bonomo, Pierluigi

AU - Alcorn, Sara R

AU - Johnstone, Candice

AU - Simone, Charles B

AU - Chao, Michael

AU - Saito, Tetsuo

AU - Hoskin, Peter J

AU - Chow, Edward

AU - Ryu, Samuel

PY - 2026/7/18

Y1 - 2026/7/18

U2 - 10.1016/j.ejca.2026.116946

DO - 10.1016/j.ejca.2026.116946

M3 - Editorial

C2 - 42492308

SN - 0959-8049

VL - 245

JO - European Journal of Cancer

JF - European Journal of Cancer

M1 - 116946

ER -