Beyond growth signaling: Paneth cells metabolically support ISCs

Talya L. Dayton; Hans Clevers

doi:10.1038/cr.2017.59

Beyond growth signaling: Paneth cells metabolically support ISCs

Talya L. Dayton, Hans Clevers^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.

Original language	English
Pages (from-to)	851-852
Number of pages	2
Journal	Cell Research
Volume	27
Issue number	7
DOIs	https://doi.org/10.1038/cr.2017.59
Publication status	Published - 1 Jul 2017

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AB - Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.

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Beyond growth signaling: Paneth cells metabolically support ISCs

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