Bewegingsstoornissen als prodroom bij personen met een sterk verhoogd risico op psychose

Background The accurate prediction of a transition to psychosis in high-risk and ultra-high-risk {uhr) populations is important because timely preventive interventions may succeed in delaying or even averting psychosis. However, current screening programmes have very low predictive power.Therefore, if prodromal signs are to be really useful they need to be objective and have strong predictive power. We hypothesise that in the prodromal phase movement disorders (md) are probably better than screening programmes at predicting the development of psychotic disorders. aim To determine, on the basis of published articles and personal experience, whether, in uhr populations, md can predict a transition to psychosis more accurately that current screening programmes. method We studied the literature using Medline. results Our strategy was to search the literature for studies concerning i. children with schizotypal personality disorder, 2. uhr adolescents and 3. siblings of patients with schizophrenia. Studies relating to the first two groups showed that the severity of md was related to the severity of the. Conclusion mD are objective easy-to-measure prodromal signs which might be powerful predictors of a transition to psychosis in (u)hr populations.