Betere functionele uitkomsten na rectumcarcinoom

Alexander J. Pennings; Geraldine R. Vink; Sander van Kuijk; Jarno Melenhorst; Geerard L. Beets; Anne M. May; Stephanie O. Breukink

Betere functionele uitkomsten na rectumcarcinoom

Translated title of the contribution: Quality of life and functional outcomes in patients with rectal carcinoma

Alexander J. Pennings, Geraldine R. Vink, Sander van Kuijk, Jarno Melenhorst, Geerard L. Beets, Anne M. May, Stephanie O. Breukink

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands. DESIGN: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019. METHOD: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time. RESULTS: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma. CONCLUSION: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.

Translated title of the contribution	Quality of life and functional outcomes in patients with rectal carcinoma
Original language	Dutch
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	169
Publication status	Published - 27 May 2025

Cite this

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title = "Betere functionele uitkomsten na rectumcarcinoom",

abstract = "OBJECTIVE: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands. DESIGN: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019. METHOD: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time. RESULTS: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma. CONCLUSION: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.",

author = "Pennings, \{Alexander J.\} and Vink, \{Geraldine R.\} and \{van Kuijk\}, Sander and Jarno Melenhorst and Beets, \{Geerard L.\} and May, \{Anne M.\} and Breukink, \{Stephanie O.\}",

year = "2025",

month = may,

day = "27",

language = "Dutch",

volume = "169",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu van Loghum",

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TY - JOUR

T1 - Betere functionele uitkomsten na rectumcarcinoom

AU - Pennings, Alexander J.

AU - Vink, Geraldine R.

AU - van Kuijk, Sander

AU - Melenhorst, Jarno

AU - Beets, Geerard L.

AU - May, Anne M.

AU - Breukink, Stephanie O.

PY - 2025/5/27

Y1 - 2025/5/27

N2 - OBJECTIVE: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands. DESIGN: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019. METHOD: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time. RESULTS: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma. CONCLUSION: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.

AB - OBJECTIVE: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands. DESIGN: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019. METHOD: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time. RESULTS: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma. CONCLUSION: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.

UR - https://www.scopus.com/pages/publications/105007053097

M3 - Article

C2 - 40433732

AN - SCOPUS:105007053097

SN - 0028-2162

VL - 169

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

ER -

Betere functionele uitkomsten na rectumcarcinoom

Abstract

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