TY - JOUR
T1 - Betere functionele uitkomsten na rectumcarcinoom
AU - Pennings, Alexander J.
AU - Vink, Geraldine R.
AU - van Kuijk, Sander
AU - Melenhorst, Jarno
AU - Beets, Geerard L.
AU - May, Anne M.
AU - Breukink, Stephanie O.
PY - 2025/5/27
Y1 - 2025/5/27
N2 - OBJECTIVE: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands. DESIGN: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019. METHOD: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time. RESULTS: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma. CONCLUSION: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.
AB - OBJECTIVE: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands. DESIGN: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019. METHOD: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time. RESULTS: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma. CONCLUSION: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.
UR - http://www.scopus.com/inward/record.url?scp=105007053097&partnerID=8YFLogxK
M3 - Article
C2 - 40433732
AN - SCOPUS:105007053097
SN - 0028-2162
VL - 169
JO - Nederlands Tijdschrift voor Geneeskunde
JF - Nederlands Tijdschrift voor Geneeskunde
ER -