betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses

Geeske M van Woerden, Freek E Hoebeek, Zhenyu Gao, Raghavendra Y Nagaraja, Casper C Hoogenraad, Steven A Kushner, Christian Hansel, Chris I De Zeeuw, Ype Elgersma

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.

Original languageEnglish
Pages (from-to)823-5
Number of pages3
JournalNature Neuroscience
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

Keywords

  • Animals
  • Calcineurin/metabolism
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics
  • Cyclosporine/pharmacology
  • Electric Stimulation
  • Enzyme Inhibitors/pharmacology
  • In Vitro Techniques
  • Long-Term Potentiation/physiology
  • Long-Term Synaptic Depression/drug effects
  • Mice
  • Mice, Knockout
  • Models, Neurological
  • Neuronal Plasticity/physiology
  • Patch-Clamp Techniques
  • Purkinje Cells/physiology
  • Synapses/physiology

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