Abstract
At routine determination of serum activities of transaminases (aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT)) increased levels are frequently found. - An algorithm may be used in the analysis of elevated transaminase levels: after elimination of the most frequent causes of hepatitis (alcoholic hepatitis, chronic hepatitis B and C) and some rare conditions (autoimmune hepatitis, α 1-antitrypsin deficiency, haemochromatosis and Wilson's disease), the diagnosis will often be nonalcoholic steatohepatitis. - Although nonalcoholic steatohepatitis is considered a stable disease, recent literature shows a progression to cirrhosis in 8-17%. - So far, no effective therapeutic strategies are available for nonalcoholic steatohepatitis.
| Translated title of the contribution | Management in increased serum aminotransferase levels without symptoms in particular in nonalcoholic steatohepatitis |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 506-509 |
| Number of pages | 4 |
| Journal | Nederlands Tijdschrift voor Geneeskunde |
| Volume | 143 |
| Issue number | 10 |
| Publication status | Published - 6 Mar 1999 |