B-cells and schizophrenia: A promising link or a finding lost in translation?

Hans C van Mierlo, Jasper C A Broen, René S Kahn, Lot D de Witte

Research output: Contribution to journalReview articlepeer-review


Recent genetic studies have suggested a potential role for B-cells in the pathogenesis of schizophrenia. Greater insight in the functioning of B-cells in patients with schizophrenia is therefore of importance. In this narrative review we aim to give an overview of the current literature on B-cells and schizophrenia. We found no evidence for altered numbers of these cells in blood. We did find support for increased levels of B-cell related cytokines and certain autoantibodies. Studies on B-cell development and function, or their numbers in cerebrospinal fluid or brain tissue are very limited. Based on the available data we appraise whether various B-cell mediated pathological mechanisms are likely to play a role in schizophrenia and provide directions for future research.

Original languageEnglish
Pages (from-to)52-62
Number of pages11
JournalBrain, Behavior, and Immunity
Publication statusPublished - Oct 2019


  • B-cells
  • GWAS
  • Genetics
  • Immunology
  • Psychosis
  • Schizophrenia


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