B-cells and schizophrenia: A promising link or a finding lost in translation?

Hans C van Mierlo; Jasper C A Broen; René S Kahn; Lot D de Witte

doi:10.1016/j.bbi.2019.06.043

B-cells and schizophrenia: A promising link or a finding lost in translation?

Hans C van Mierlo, Jasper C A Broen, René S Kahn, Lot D de Witte

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent genetic studies have suggested a potential role for B-cells in the pathogenesis of schizophrenia. Greater insight in the functioning of B-cells in patients with schizophrenia is therefore of importance. In this narrative review we aim to give an overview of the current literature on B-cells and schizophrenia. We found no evidence for altered numbers of these cells in blood. We did find support for increased levels of B-cell related cytokines and certain autoantibodies. Studies on B-cell development and function, or their numbers in cerebrospinal fluid or brain tissue are very limited. Based on the available data we appraise whether various B-cell mediated pathological mechanisms are likely to play a role in schizophrenia and provide directions for future research.

Original language	English
Pages (from-to)	52-62
Number of pages	11
Journal	Brain, Behavior, and Immunity
Volume	81
DOIs	https://doi.org/10.1016/j.bbi.2019.06.043
Publication status	Published - Oct 2019

Keywords

B-cells
GWAS
Genetics
Immunology
Psychosis
Schizophrenia

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title = "B-cells and schizophrenia: A promising link or a finding lost in translation?",

abstract = "Recent genetic studies have suggested a potential role for B-cells in the pathogenesis of schizophrenia. Greater insight in the functioning of B-cells in patients with schizophrenia is therefore of importance. In this narrative review we aim to give an overview of the current literature on B-cells and schizophrenia. We found no evidence for altered numbers of these cells in blood. We did find support for increased levels of B-cell related cytokines and certain autoantibodies. Studies on B-cell development and function, or their numbers in cerebrospinal fluid or brain tissue are very limited. Based on the available data we appraise whether various B-cell mediated pathological mechanisms are likely to play a role in schizophrenia and provide directions for future research.",

keywords = "B-cells, GWAS, Genetics, Immunology, Psychosis, Schizophrenia",

author = "{van Mierlo}, {Hans C} and Broen, {Jasper C A} and Kahn, {Ren{\'e} S} and {de Witte}, {Lot D}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

doi = "10.1016/j.bbi.2019.06.043",

language = "English",

volume = "81",

pages = "52--62",

journal = "Brain, Behavior, and Immunity",

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T1 - B-cells and schizophrenia

T2 - A promising link or a finding lost in translation?

AU - van Mierlo, Hans C

AU - Broen, Jasper C A

AU - Kahn, René S

AU - de Witte, Lot D

PY - 2019/10

Y1 - 2019/10

N2 - Recent genetic studies have suggested a potential role for B-cells in the pathogenesis of schizophrenia. Greater insight in the functioning of B-cells in patients with schizophrenia is therefore of importance. In this narrative review we aim to give an overview of the current literature on B-cells and schizophrenia. We found no evidence for altered numbers of these cells in blood. We did find support for increased levels of B-cell related cytokines and certain autoantibodies. Studies on B-cell development and function, or their numbers in cerebrospinal fluid or brain tissue are very limited. Based on the available data we appraise whether various B-cell mediated pathological mechanisms are likely to play a role in schizophrenia and provide directions for future research.

AB - Recent genetic studies have suggested a potential role for B-cells in the pathogenesis of schizophrenia. Greater insight in the functioning of B-cells in patients with schizophrenia is therefore of importance. In this narrative review we aim to give an overview of the current literature on B-cells and schizophrenia. We found no evidence for altered numbers of these cells in blood. We did find support for increased levels of B-cell related cytokines and certain autoantibodies. Studies on B-cell development and function, or their numbers in cerebrospinal fluid or brain tissue are very limited. Based on the available data we appraise whether various B-cell mediated pathological mechanisms are likely to play a role in schizophrenia and provide directions for future research.

KW - B-cells

KW - GWAS

KW - Genetics

KW - Immunology

KW - Psychosis

KW - Schizophrenia

U2 - 10.1016/j.bbi.2019.06.043

DO - 10.1016/j.bbi.2019.06.043

M3 - Review article

C2 - 31271869

SN - 0889-1591

VL - 81

SP - 52

EP - 62

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

ER -

B-cells and schizophrenia: A promising link or a finding lost in translation?

Abstract

Keywords

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