Axons Navigate Noise with 190RhoGAP

Pavol Zelina; R. Jeroen Pasterkamp

doi:10.1016/j.neuron.2019.04.024

Axons Navigate Noise with 190RhoGAP

Pavol Zelina, R. Jeroen Pasterkamp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the embryonic spinal cord.

Original language	English
Pages (from-to)	512-514
Number of pages	3
Journal	Neuron
Volume	102
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2019.04.024
Publication status	Published - 8 May 2019

Keywords

Axon Guidance
Axons
DCC Receptor
Nerve Growth Factors
Netrin-1
Tumor Suppressor Proteins

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10.1016/j.neuron.2019.04.024

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title = "Axons Navigate Noise with 190RhoGAP",

abstract = "In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the embryonic spinal cord.",

keywords = "Axon Guidance, Axons, DCC Receptor, Nerve Growth Factors, Netrin-1, Tumor Suppressor Proteins",

author = "Pavol Zelina and Pasterkamp, {R. Jeroen}",

year = "2019",

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AU - Pasterkamp, R. Jeroen

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AB - In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the embryonic spinal cord.

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KW - Axons

KW - DCC Receptor

KW - Nerve Growth Factors

KW - Netrin-1

KW - Tumor Suppressor Proteins

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M3 - Article

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VL - 102

SP - 512

EP - 514

JO - Neuron

JF - Neuron

IS - 3

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Axons Navigate Noise with 190RhoGAP

Abstract

Keywords

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