TY - JOUR
T1 - Automated auditory brainstem response in preterm newborns with histological chorioamnionitis
AU - Smit, Adriana L.
AU - Been, Jasper V.
AU - Zimmermann, Luc J I
AU - Kornelisse, Rene F.
AU - Andriessen, Peter
AU - Vanterpool, Sizzle F.
AU - Bischoff, Martijn P H
AU - Stokroos, Robert J.
AU - De Krijger, Ronald R.
AU - Kremer, Bernd
AU - Kramer, Boris W.
PY - 2015/10/13
Y1 - 2015/10/13
N2 - Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.
AB - Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.
KW - Automated auditory brainstem response
KW - chorioamnionitis
KW - hearing screening
KW - preterm infants
UR - http://www.scopus.com/inward/record.url?scp=84940763858&partnerID=8YFLogxK
U2 - 10.3109/14767058.2014.971747
DO - 10.3109/14767058.2014.971747
M3 - Article
C2 - 25294170
AN - SCOPUS:84940763858
SN - 1476-7058
VL - 28
SP - 1864
EP - 1869
JO - Journal of Maternal-fetal & Neonatal Medicine
JF - Journal of Maternal-fetal & Neonatal Medicine
IS - 15
ER -