Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity

Maarten R Hillen; Katia Urso; Emma Koppe; Ana Pinheiro Lopes; Sofie L M Blokland; Aridaman Pandit; Tom Slocombe; André van Maurik; Joel A G van Roon; Timothy R D J Radstake

doi:10.1136/rmdopen-2020-001184

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity

Maarten R Hillen, Katia Urso, Emma Koppe, Ana Pinheiro Lopes, Sofie L M Blokland, Aridaman Pandit, Tom Slocombe, André van Maurik, Joel A G van Roon, Timothy R D J Radstake

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Article number	e001184
Number of pages	5
Journal	RMD Open
Volume	6
Issue number	2
DOIs	https://doi.org/10.1136/rmdopen-2020-001184
Publication status	Published - Jul 2020

Keywords

Autoimmunity
Inflammation
Sjøgren's Syndrome
type-I interferon
Sjogren's Syndrome
autoantibodies

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10.1136/rmdopen-2020-001184

e001184.fullFinal published version, 738 KB

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Hillen, M. R., Urso, K., Koppe, E., Lopes, A. P., Blokland, S. L. M., Pandit, A., Slocombe, T., van Maurik, A., van Roon, J. A. G., & Radstake, T. R. D. J. (2020). Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity. RMD Open, 6(2), Article e001184. https://doi.org/10.1136/rmdopen-2020-001184

@article{1c67bad62c6340709ec0b32b1baf8eef,

title = "Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sj{\"o}gren's syndrome is associated with B cell hyperactivity and type I interferon activity",

keywords = "Autoimmunity, Inflammation, Sj{\o}gren's Syndrome, type-I interferon, Sjogren's Syndrome, autoantibodies",

author = "Hillen, {Maarten R} and Katia Urso and Emma Koppe and Lopes, {Ana Pinheiro} and Blokland, {Sofie L M} and Aridaman Pandit and Tom Slocombe and {van Maurik}, Andr{\'e} and {van Roon}, {Joel A G} and Radstake, {Timothy R D J}",

note = "Funding Information: Contributors MRH, KU, EK, AvM, JAGvR and TRDJR made substantial contributions to conception and design. MH, KU, SB, and TS were involved in sample collection. MRH, KU, and AP performed data analysis. MRH and KU drafted the paper. All authors were involved in data interpretation and revision of the paper for important intellectual content. All authors approved the final manuscript. Funding This work was in part funded by GlaxoSmithKline. MH was supported by the Dutch Arthritis Society (ReumaNederland, grant nr 17-2-301). Competing interests TR is a principal investigator in the Immunology Catalyst programme at GlaxoSmithKline, which is an independent research programme. He did not receive any financial support other than the research funding for the current project. The other authors have declared no conflicts of interest. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = jul,

doi = "10.1136/rmdopen-2020-001184",

language = "English",

volume = "6",

journal = "RMD Open",

issn = "2056-5933",

publisher = "BMJ Publishing Group",

number = "2",

}

Hillen, MR, Urso, K, Koppe, E, Lopes, AP, Blokland, SLM, Pandit, A, Slocombe, T, van Maurik, A, van Roon, JAG & Radstake, TRDJ 2020, 'Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity', RMD Open, vol. 6, no. 2, e001184. https://doi.org/10.1136/rmdopen-2020-001184

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity. / Hillen, Maarten R; Urso, Katia; Koppe, Emma et al.
In: RMD Open, Vol. 6, No. 2, e001184, 07.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity

AU - Hillen, Maarten R

AU - Urso, Katia

AU - Koppe, Emma

AU - Lopes, Ana Pinheiro

AU - Blokland, Sofie L M

AU - Pandit, Aridaman

AU - Slocombe, Tom

AU - van Maurik, André

AU - van Roon, Joel A G

AU - Radstake, Timothy R D J

N1 - Funding Information: Contributors MRH, KU, EK, AvM, JAGvR and TRDJR made substantial contributions to conception and design. MH, KU, SB, and TS were involved in sample collection. MRH, KU, and AP performed data analysis. MRH and KU drafted the paper. All authors were involved in data interpretation and revision of the paper for important intellectual content. All authors approved the final manuscript. Funding This work was in part funded by GlaxoSmithKline. MH was supported by the Dutch Arthritis Society (ReumaNederland, grant nr 17-2-301). Competing interests TR is a principal investigator in the Immunology Catalyst programme at GlaxoSmithKline, which is an independent research programme. He did not receive any financial support other than the research funding for the current project. The other authors have declared no conflicts of interest. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/7

Y1 - 2020/7

KW - Autoimmunity

KW - Inflammation

KW - Sjøgren's Syndrome

KW - type-I interferon

KW - Sjogren's Syndrome

KW - autoantibodies

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U2 - 10.1136/rmdopen-2020-001184

DO - 10.1136/rmdopen-2020-001184

M3 - Article

C2 - 32540951

SN - 2056-5933

VL - 6

JO - RMD Open

JF - RMD Open

IS - 2

M1 - e001184

ER -

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren's syndrome is associated with B cell hyperactivity and type I interferon activity

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