Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Pim M J Rullens; Jop Kind

doi:10.1016/j.ceb.2020.11.006

Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Pim M J Rullens, Jop Kind

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Abstract

A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	70
DOIs	https://doi.org/10.1016/j.ceb.2020.11.006
Publication status	Published - Jun 2021

Keywords

3D genome organization
Chromatin compartments
Lamina-associated domains
Topologically associating domains

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1-s2.0-S0955067420301563-mainFinal published version, 1.08 MBLicence: CC BY

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title = "Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome",

abstract = "A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.",

keywords = "3D genome organization, Chromatin compartments, Lamina-associated domains, Topologically associating domains",

author = "Rullens, \{Pim M J\} and Jop Kind",

note = "Funding Information: The authors thank the members of the Kind lab for critical reading of the manuscript. This work was funded by a European Research Council Starting grant (no. ERC-StG 678423-EpiID ) and a Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) VIDI grant (no. 161.339 ). Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = jun,

doi = "10.1016/j.ceb.2020.11.006",

language = "English",

volume = "70",

pages = "51--57",

journal = "Current Opinion in Cell Biology",

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AU - Rullens, Pim M J

AU - Kind, Jop

N1 - Funding Information: The authors thank the members of the Kind lab for critical reading of the manuscript. This work was funded by a European Research Council Starting grant (no. ERC-StG 678423-EpiID ) and a Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) VIDI grant (no. 161.339 ). Publisher Copyright: © 2020 The Authors

PY - 2021/6

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N2 - A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

AB - A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

KW - 3D genome organization

KW - Chromatin compartments

KW - Lamina-associated domains

KW - Topologically associating domains

UR - https://www.scopus.com/pages/publications/85098204699

U2 - 10.1016/j.ceb.2020.11.006

DO - 10.1016/j.ceb.2020.11.006

M3 - Review article

C2 - 33360765

SN - 0955-0674

VL - 70

SP - 51

EP - 57

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

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Keywords

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