Atracurium during induced hyperthermia

Gersten Jonker*, Leo J. Hoogenboom, Bert Ramshorst, Peter Bruins

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


During hyperthermic intraperitoneal chemotherapy (HIPEC), we observed a partial recovery from neuromuscular block in a hyperthermic patient after hours of monitored adequate surgical relaxation and continuous infusion of atracurium during normothermia. This recovery is indicative of the higher clearance of atracurium during hyperthermia. This case report emphasizes the clinical relevance of the well-known temperature dependence of the Hofmann elimination of atracurium. Moreover, this report illustrates the importance of monitoring muscle relaxation during HIPEC. Clinicians should be aware that the usual continuous infusion rate of atracurium at 0.3 mg·kg-1·h-1 may be inadequate in hyperthermic patients.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalJournal of Anesthesia
Issue number3
Publication statusPublished - 27 Aug 2009


  • Atracurium
  • Hyperthermia
  • Monitoring
  • Neuromuscular block
  • Neuromuscular function


Dive into the research topics of 'Atracurium during induced hyperthermia'. Together they form a unique fingerprint.

Cite this