Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography

Nick S. Nurmohamed; Alexander R. van Rosendael; Ibrahim Danad; Quyen Ngo-Metzger; Pam R. Taub; Kausik K. Ray; Gemma Figtree; Marc P. Bonaca; Judith Hsia; Fatima Rodriguez; Alexander T. Sandhu; Koen Nieman; James P. Earls; Udo Hoffmann; Jeroen J. Bax; James K. Min; David J. Maron; Deepak L. Bhatt

doi:10.1093/eurheartj/ehae190

Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography

Nick S. Nurmohamed, Alexander R. van Rosendael, Ibrahim Danad, Quyen Ngo-Metzger, Pam R. Taub, Kausik K. Ray, Gemma Figtree, Marc P. Bonaca, Judith Hsia, Fatima Rodriguez, Alexander T. Sandhu, Koen Nieman, James P. Earls, Udo Hoffmann, Jeroen J. Bax, James K. Min, David J. Maron, Deepak L. Bhatt^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual’s complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.

Original language	English
Pages (from-to)	1783-1800
Number of pages	18
Journal	European heart journal
Volume	45
Issue number	20
DOIs	https://doi.org/10.1093/eurheartj/ehae190
Publication status	Published - 21 May 2024

Keywords

Atherosclerotic cardiovascular disease
Coronary artery disease
Coronary computed tomography angiography
Major adverse cardiovascular events
Prevention

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ehae190Final published version, 1.2 MBLicence: CC BY

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Nurmohamed, N. S., van Rosendael, A. R., Danad, I., Ngo-Metzger, Q., Taub, P. R., Ray, K. K., Figtree, G., Bonaca, M. P., Hsia, J., Rodriguez, F., Sandhu, A. T., Nieman, K., Earls, J. P., Hoffmann, U., Bax, J. J., Min, J. K., Maron, D. J., & Bhatt, D. L. (2024). Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography. European heart journal, 45(20), 1783-1800. https://doi.org/10.1093/eurheartj/ehae190

@article{d1c6beaf29954f4ca0f7797c4baa0c3b,

title = "Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography",

abstract = "Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual{\textquoteright}s complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.",

keywords = "Atherosclerotic cardiovascular disease, Coronary artery disease, Coronary computed tomography angiography, Major adverse cardiovascular events, Prevention",

author = "Nurmohamed, {Nick S.} and {van Rosendael}, {Alexander R.} and Ibrahim Danad and Quyen Ngo-Metzger and Taub, {Pam R.} and Ray, {Kausik K.} and Gemma Figtree and Bonaca, {Marc P.} and Judith Hsia and Fatima Rodriguez and Sandhu, {Alexander T.} and Koen Nieman and Earls, {James P.} and Udo Hoffmann and Bax, {Jeroen J.} and Min, {James K.} and Maron, {David J.} and Bhatt, {Deepak L.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = may,

day = "21",

doi = "10.1093/eurheartj/ehae190",

language = "English",

volume = "45",

pages = "1783--1800",

number = "20",

}

Nurmohamed, NS, van Rosendael, AR, Danad, I, Ngo-Metzger, Q, Taub, PR, Ray, KK, Figtree, G, Bonaca, MP, Hsia, J, Rodriguez, F, Sandhu, AT, Nieman, K, Earls, JP, Hoffmann, U, Bax, JJ, Min, JK, Maron, DJ & Bhatt, DL 2024, 'Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography', European heart journal, vol. 45, no. 20, pp. 1783-1800. https://doi.org/10.1093/eurheartj/ehae190

TY - JOUR

T1 - Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography

AU - Nurmohamed, Nick S.

AU - van Rosendael, Alexander R.

AU - Danad, Ibrahim

AU - Ngo-Metzger, Quyen

AU - Taub, Pam R.

AU - Ray, Kausik K.

AU - Figtree, Gemma

AU - Bonaca, Marc P.

AU - Hsia, Judith

AU - Rodriguez, Fatima

AU - Sandhu, Alexander T.

AU - Nieman, Koen

AU - Earls, James P.

AU - Hoffmann, Udo

AU - Bax, Jeroen J.

AU - Min, James K.

AU - Maron, David J.

AU - Bhatt, Deepak L.

PY - 2024/5/21

Y1 - 2024/5/21

N2 - Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual’s complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.

AB - Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual’s complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.

KW - Atherosclerotic cardiovascular disease

KW - Coronary artery disease

KW - Coronary computed tomography angiography

KW - Major adverse cardiovascular events

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=85194468791&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehae190

DO - 10.1093/eurheartj/ehae190

M3 - Review article

AN - SCOPUS:85194468791

SN - 0195-668X

VL - 45

SP - 1783

EP - 1800

JO - European heart journal

JF - European heart journal

IS - 20

ER -

Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography

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